The Discipline of Toxicologic Pathology

Toxicologic pathology is a biomedical specialty that integrates the science of toxicology (study of poisons) and pathology (study of disease). Both toxicology and pathology are critical components of the safety assessment process used in predicting human and animal responses to drugs, chemicals, and therapeutic devices, including identifying the potential of these agents to cause cancer. The toxicologic pathology discipline also studies adverse environmental exposure responses in aquatic organisms, domesticated and wild animals, and humans. In addition to morphological diagnoses of organ and tissue pathology, toxicologic pathology includes identifying injury at the cellular, subcellular, and molecular levels to identify the health consequences of the adverse effects of drugs, chemicals, and therapeutic devices on aging, genetics, nutrition, immune function, developmental biology, reproduction, and brain development. The discipline of toxicologic pathology is heavily involved in development and safety assessment of new candidate drugs, pesticides, new medical implants, food additives, over the counter herbal products, and genetically modified foods with a primary objective of improving human, animal, and environmental health.

toxicologic pathology

Toxicologic Pathology Articles and Publications

ashitaba chalcone - toxicologic pathology

Toxicological Assessment of Ashitaba Chalcone

The plant Angelica keiskei contains two main physiologically active flavonoid chalcones, 4-hydroxyderricin and xanthoangelol. Known as ashitaba in Japan, powder from the sap is widely consumed for its medicinal properties in Asia as a dietary supplement […]


Human Relevance Of Rodent Leydig Cell Tumors

Rodents have been used extensively in virtually all fields of biomedical research and have been the primary species used in toxicologic and carcinogenic research. Over many years it has become obvious that some conditions […]


Two-year Carcinogenicity Study of Acrylamide in Wistar Han Rats with In Utero Exposure

Acrylamide is an important chemical with widespread industrial and other uses in addition to generalized population exposure from certain cooked foods. Previous rat studies to assess the carcinogenic potential […]


Practical Applications of in Vivo and ex Vivo MRI in Toxicologic Pathology Using a Novel High-performance Compact MRI System

Magnetic resonance imaging (MRI) is widely used in preclinical research and drug development and is a powerful noninvasive […]

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Toxicologic Pathology Lectures

Pathology of the Adrenal Gland - toxicologic pathology

This toxicologic pathology presentation provided examples of normal, degenerative lesions of the rat and mouse adrenal gland and includes non-neoplastic proliferative lesions as well as common and rare adrenal cortical and medullary cancers.

hepatotoxicity - toxicologic pathology

A toxicologic pathology overview of liver toxicity including clinical and anatomic pathology, histopathology of toxic liver lesions, factors that influence liver toxicologic pathology, and case examples for establishing a NOAEL.

rat liver foci toxicologic pathology

A gallery of photomicrographs depicting the spectrum of foci of cellular alteration in the rat liver that might be encountered during toxicologic pathology evaluation of preclinical studies.

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toxicologic pathology
Robert Maronpot toxicologic pathology

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP, was selected by the Awards Committee as the 2008 Society of Toxicologic Pathology Achievement Award recipient. Dr. Maronpot has significantly influenced the field of toxicologic pathology in many different ways, including as a leader, manager, educator, and author. He is internationally recognized and highly respected for his scientific contributions to toxicologic pathology and the advancement of the Society of Toxicologic Pathology (STP). Dr. Maronpot served as president of STP in 2001 and as editor-in-chief of its journal, Toxicologic Pathology, from 2001 to 2004.

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Robert R. Maronpot BioSketch and CV

Consultant in Toxicology and Pathology
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