Measurement of Cell Replication and Apoptosis in Mice

Maronpot et al., 2000. Chapter 5 in Pathology of Genetically Engineered Mice. Iowa State University Press. This chapter focuses primarily on practical methods for assessing cell proliferation and apoptosis in tissue sections from mice, including administration of BrdU in drinking water. Key words: cell cycle, BrdU, PCNA, osmotic minipumps, study design.