Yearly Archives: 2016

/2016

Recommendations from the INHAND Apoptosis/Necrosis Working Group

Historically, there has been confusion relating to the diagnostic nomenclature for individual cell death. Toxicologic pathologists have generally used the terms “single cell necrosis” and “apoptosis” interchangeably. Increased research on the mechanisms of cell death in recent years has led to the understanding that apoptosis and necrosis involve different cellular pathways and that these differences [...]

Ninety-day toxicity and single-dose toxicokinetics study of alpha-glycosyl isoquercitrin in Sprague-Dawley rat

alpha-Glycosyl isoquercitrin (AGIQ) is highly absorbable and has been shown to possess antioxidative properties. Based on a favorable safety profile, it has been confirmed as generally recognized as safe (GRAS) compound by the FDA. Nevertheless, safety and toxicity information for AGIQ is still sparse. Therefore, the aim of this study was to test the safety [...]

Genotoxicity Assessment of the Flavouring Agent, Perillaldehyde

Perillaldehyde, a natural monocyclic terpenoid found most abundantly in the herb perilla, has a long history of use as a flavouring ingredient to add spiciness and citrus taste to foods. Previously, it was judged to be safe by several international expert panels. To confirm the safety of flavourings placed on the European Union list of [...]

The Legacy of the F344 Rat as a Cancer Bioassay Model (A Retrospective Summary of Three Common F344 Neoplasms)

Robert R. Maronpot1, Abraham Nyska2, Jennifer E. Foreman3, Yuval Ramot4 1Maronpot Consulting LLC, Raleigh, North Carolina, USA, 2Sackler School of Medicine, Tel Aviv University and Timrat, Israel, 3ExxonMobil Biomedical Sciences, Inc., Annadale, New Jersey, USA,  4Hadassah-Hebrew University Medical Center, Jerusalem, Israel Keywords: Mononuclear cell leukemia, LGL leukemia, Leydig cell tumor, tunica vaginalis mesothelioma, cancer bioassay, carcinogenesis [...]

Genetic and Rat Toxicity Studies of Cyclodextrin Glucanotransferase

Highlights • Bacterial cyclodextrin glucanotransferase (CGTase) is used to produce a water soluble form of glycosylated isoquercitrin. • Genotoxicity battery on CGTase and sodium sulfate negative for mutations and DNA damage. • No evidence of systemic toxicity in 90-day rat toxicity study of CGTase Introduction Microbiologically derived cyclodextrin glucanotransferase (CGTase) is used commercially as a processing agent in [...]

Recommendations from the INHAND Apoptosis/Necrosis Working Group

Historically, there has been confusion relating to the diagnostic nomenclature for individual cell death. Toxicologic pathologists have generally used the terms ‘‘single cell necrosis’’ and ‘‘apoptosis’’ interchangeably. Increased research on the mechanisms of cell death in recent years has led to the understanding that apoptosis and necrosis involve different cellular pathways and that these differences [...]