Robert Maronpot toxicologic pathology

Robert Maronpot Toxicologic Pathologist

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, was selected by the Awards Committee as the 2008 Society of Toxicologic Pathology Achievement Award recipient. Dr. Maronpot has significantly influenced the field of toxicologic pathology in many different ways, including as a leader, manager, educator, and author. He is internationally recognized and highly respected for his scientific contributions to toxicologic pathology and the advancement of the Society of Toxicologic Pathology (STP). Dr. Maronpot served as president of STP in 2001 and as editor-in-chief of its journal, Toxicologic Pathology, from 2001 to 2004.
     Dr. Maronpot received his doctorate of veterinary medicine in 1965 from Michigan State University, an MS in nutritional pathology from Michigan State University in 1966, and an MPH from Harvard University in 1972. He is a diplomate of the American College of Veterinary Pathologists as well as the American Board of Toxicology and has worked more than forty years in experimental pathology, with an emphasis on animal models of carcinogenesis. He serves on several journal editorial boards.
     In addition to more than 300 peer-reviewed publications, he has edited a comprehensive text titled Pathology of the Mouse (1999), coedited a book titled Pathology of Genetically Engineered Mice (2000), and has several years of experience in the application of imaging technologies, especially magnetic resonance imaging (MRI), to toxicologic pathology. In 2007, he retired from the National Institute of Environmental Health Sciences (NIEHS) and the National Toxicology Program (NTP), where he was chief of the Laboratory of Experimental Pathology.
     As a leader and manager, he started at the NIEHS as part of a very small, fledgling program of experimental pathology in 1981. During his appointment, his vision of increasing the impact of the pathologist in toxicology through a wider use of scientific tools was so successful that, by the end of his tenure, the program had expanded to fifty people, all dedicated to the elucidation of scientific issues in pathology. The pathologists on the current staff at NIEHS joined the program during his tenure and constitute a remarkable group of scientists.
     As an educator, Dr. Maronpot also created the training program at NIEHS, where many toxicologic pathologists have been trained through the years. The program maintains two to three trainees, therefore creating a scholarly learning environment. He was the originator of the NTP Symposium held in conjunction with the STP Symposium that has always been well received and considered an important component of the meeting. Dr. Maronpot also has adjunct faculty appointments at Duke University, North Carolina State University, and the University of North Carolina.
     In addition to his leadership role as editor of the Pathology of the Mouse, which is a seminal publication to all toxicologic pathologists, he was instrumental in organizing some of the first panels of pathologists to achieve better standardization of our terminology. Specifically impactful was his leadership in the definition of liver proliferative lesions as well as his role in the nomenclature of lesions of the forestomach. These early efforts set the tone for the achievement of consensus in the field and have been critical to the later achievement of clarity in our communication of risk assessment. Dr. Maronpot also contributed significantly to the use of in vivo imaging, particularly MRI and its use in the study of the development, progression, and regression of proliferative changes in rodents.
     Dr. Maronpot continues to advance the profession by working as a consultant and striving to address some of the issues of consistency between pathologists. He is frequently sought out to provide expert advice on numerous national and international committees, working groups, and task forces. He serves as an example to the present and future membership for his scientific achievements and selfless dedication to the profession.

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R. R. Maronpot

Consultant in Toxicology and Pathology
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Robert Maronpot Curriculum Vitae September 2015

Maronpot Consulting, LLC
Email: Maronpot@me.com

Education:

Michigan State University, B.S., 1963.
Michigan State University, D.V.M., 1965.
Michigan State University, M.S., 1966.
Harvard University, M.P.H., 1972.

Certifications/Licensure:

Diplomate, American College of Veterinary Pathologists, 1973
Diplomate, American Board of Toxicology, 1980

Expertise/Interests:

Carcinogenesis
Hepatic Pathology
Respiratory System Pathology
Preclinical Safety Assessment

Present Position and Background:

2007 – Present Maronpot Consulting, LLC, 1612 Medfield Road, Raleigh, NC

1992 – 2006 Chief, Laboratory of Experimental Pathology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC

1991 – 1992 Chief, Experimental Toxicology Branch, National Toxicology Program
National Institute of Environmental Health Sciences, Research Triangle Park, NC

1990 – 1991 Cancer Genetics & Molecular Pathology, Experimental Carcinogenesis & Branch, National Institute of Environmental Health Sciences, Triangle Park, NC

1989 – 1993 Board of Directors, American Board of Toxicology, Washington, D.C.
University of North Carolina, Chapel Hill, NC

1981 – 1990 Head, Experimental Pathology, Chemical Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences,
Research Triangle Park, NC

1978 – 1981 Fellow, Bushy Run Research Center, Carnegie-Mellon University
4400 Fifth Avenue, Pittsburg, PA

1975 – 1978 Head, Pathology Department, Chemical Hygiene Fellowship, Carnegie-Mellon Institute of Research, 4400 Fifth Avenue, Pittsburg, PA

1974 – 1975 Head, Research Animal Facility

1974 – 1975 Acting Head, Experimental Pathology Division, Naylor Dana Institute for Disease, American Health Foundation, Valhalla, New York

1974 – 1975 Clinical Assistant Professor of Pathology, New York Medical College,
Valhalla, NY

1975 Consultant in Veterinary Pathology, Memorial Sloan-Kettering Cancer Research Center, New York, NY

1972 – 1974 Research Fellow in Comparative Pathology, Pathology Department, Harvard Medical School and Angell Memorial Animal Hospital
Boston, MA

1971 – 1972 Research Fellow in Public Health, Microbiology Department, Harvard School of Health, Boston Massachusetts
Valhalla, NY

1968 – 1971 Head, Veterinary Medicine Department, U.S. Naval Medical Research Unit #3,Cairo, Egypt

1966 – 1968 Veterinary Laboratory Officer, Veterinary Corps, U.S. Army Pathology Division, U.S. Army Medical Research and Nutrition Laboratory, Denver, CO

1965 – 1966 NIH Postdoctoral Fellow, Pathology Department, Michigan State University, Lansing, MI

Professional Memberships and Affiliations:

American College of Veterinary Pathologists
Society of Toxicologic Pathologists
Society of Toxicology
International Academy of Toxicologic Pathology

Honors And Awards:

President, International Academy of Toxicologic Pathology, 2011-2012
Vice President, International Academy of Toxicologic Pathology ,2010
Fellow, International Academy of Toxicologic Pathology, 2009
Society of Toxicologic Pathology Achievement Award, 2008
Board of Directors, American Board of Toxicology, 1989-1993
Editor-in-Chief, Toxicologic Pathology, 2001-2004
President, Society of Toxicologic Pathology, 2001-2002
Distinguished Postdoctoral Veterinary Alumnus Award from Michigan State University
College of Veterinary Medicine – 2000
Diplomate, American Board of Toxicology, 1980
Diplomate, American College of Veterinary Pathologists, 1973

Publications And Papers:

Ramot, Y., Nyska, A., Markovitz, E., Dekel, A., Klaiman, G., Zada, M.H., Domb, A.J., and Maronpot, R. R. (2015) Long-term local and Systemic Safety of Poly(L-lactide-co-epsilon-caprolactone) after Subcutaneous ad Intra-articular Implantation in Rats. Toxicol Pathol DOI: 10.1177/0192623315600275.

Hobbs, C.A., Swartz, C., Maronpot, R., Davis, J., Recio, L., Koyanagi, M., and Hayashi, S. (2015) Genotoxicity Evaluation of the Flavonoid, Myricitrin, and its Aglycone, Myricetin. Food Chem Toxicol 83: 283-292.

Tempel-Brami, C., Schiffenbauer, Y.S., Nyska, A., Ezov, N., Spector, I., Abramovitch, R., and Maronpot, R.R. (2015). Practical Applications of in Vivo and ex Vivo MRI in Toxicologic Pathology Using a Novel High-performance Compact MRI System. Toxicol Pathol 43: 633-650.

Maronpot, R. R. (2015) Toxicolgical Assessment of Ashitaba Chalcone. Food & Chemical Toxicology 77: 111-119.

Maronpot, R. R., Thoolen, R.J.M.M., and Hansen, B. (2015) Two-Year Carcinogenicity Study of Acrylamide in Wistar Han Rats with in Utero Exposure. Experimental and Toxicologic Pathology 67: 189-195.

Branca, R. T., Zhang, L., Warren, W. S., Auerbach, E., Khanna, A., Degan, S., Ugurbil, K., and Maronpot, R. (2013). In Vivo Noninvasive Detection of Brown Adipose Tissue through Intermolecular Zero-Quantum MRI. PLoS One 8, e74206.

Elmore, S. A., Hoenerhoff, M., Katsuta, O., Kokoshima, H., Maronpot, R., Nagai, H., Satoh, H., Tanaka, Y., Tochitani, T., Tsuchiya, S., and Yoshizawa, K. (2013). Proceedings of the 2013 Joint JSTP/NTP Satellite Symposium. J Toxicol Pathol 26, 231-257.

Maronpot, R. R. (2013). The Role of the Toxicologic Pathologist in the Post-Genomic Era. J Toxicol Pathol 26, 105-110.

Maronpot, R.R., Davis, J., Moser, G., Giri, D.K. & Hayashi, S.M. (2013). Evaluation of 90-day Oral Rat Toxicity Studies on the Food Additive Gum Ghatti. Food Chem Toxicol. 51, 215-224.

Maronpot, R.R. (2012). Regulatory Forum Opinion Piece: the Role of the Toxicologic Pathologist in the Postgenomic Era: Challenges and Opportunities. Toxicol Pathol, 40, 1082-1086.

Thoolen, B., Ten Kate, F.J., van Diest, P.J., Malarkey, D.E., Elmore, S.A. & Maronpot, R.R. (2012). Comparative Histomorphological Review of Rat and Human Hepatocellular Proliferative Lesions. J Toxicol Pathol, 25, 189-199.

Carter, C.A., Misra, M. & Maronpot, R.R. (2012). Tracheal Morphologic and Protein Alterations FollowingShort-Term Cigarette Mainstream Smoke Exposure to Rats. J Toxicol Pathol, 25, 201-207.

Hobbs, C.A., Swartz, C., Maronpot, R., Davis, J., Recio, L., and Hayashi, S.M. 2012. Evaluation of the Genotoxicity of the Food Additive Gum Ghatti. Food Chem Toxicol 50:854-860.

A Review of Adaptive (Adverse and Non-adverse) Changes–Conclusions from the 3rd International ESTP Expert Workshop. Toxicol Pathol, 40, 971-994.
Hall, A.P., Elcombe, C.R., Foster, J.R., Harada, T., Kaufmann, W., Knippel, A., Kuttler, K., Malarkey, D.E., Maronpot, R.R., Nishikawa, A., Nolte, T., Schulte, A., Strauss, V. & York, M.J. (2012). Liver Hypertrophy:

Adams, E. T., Auerbach, S., Blackshear, P. E., Bradley, A., Gruebbel, M. M., Little, P. B., Malarkey, D., Maronpot, R., McKay, J. S., Miller, R. A., Moore, R. R., Morrison, J. P., Nyska, A., Ramot, Y., Rao, D., Suttie, A., Wells, M. Y., Willson, G. A., and Elmore, S. A. (2011).
Proceedings of the 2010 National Toxicology Program Satellite Symposium. Toxicol Pathol 39, 240-266.

Thoolen, B., Maronpot, R. R., Harada, T., Nyska, A., Rousseaux, C., Nolte, T., Malarkey, D. E., Kaufmann, W., Kuttler, K., Deschl, U., Nakae, D., Gregson, R., Vinlove, M. P., Brix, A. E., Singh, B., Belpoggi, F., and Ward, J. M. (2010). Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System. Toxicol Pathol 38, 5S-81S.

Villarreal-Calderon, R., Torres-Jardon, R., Palacios-Moreno, J., Osnaya, N., Perez-Guille, B., Maronpot, R. R., Reed, W., Zhu, H., and Calderon-Garciduenas, L. (2010). Urban Air Pollution Rargets the Dorsal Vagal Complex and Dark Chocolate Offers Neuroprotection. Int J Toxicol 29, 604-615.

Boorman, G. A., Wolf, D. C., Francke-Carroll, S., and Maronpot, R. R. (2010). Pathology Peer Review. Toxicol Pathol 38, 1009-1010.

Bach, U., Hailey, J. R., Hill, G. D., Kaufmann, W., Latimer, K. S., Malarkey, D. E., Maronpot, R. M., Miller, R. A., Moore, R. R., Morrison, J. P., Nolte, T., Rinke, M., Rittinghausen, S., Suttie, A. W., Travlos, G. S., Vahle, J. L., Willson, G. A., and Elmore, S. A. (2010). Proceedings of the 2009 National Toxicology Program Satellite Symposium. Toxicol Pathol 38, 9-36.

Maronpot, R. R., Yoshizawa, K., Nyska, A., Harada, T., Flake, G., Mueller, G., Singh, B., and Ward, J. M. (2010). Hepatic Enzyme Induction: Histopathology. Toxicol Pathol 38, 776-795.

Botts, S., Ennulat, D., Francke-Carroll, S., Graham, M., Maronpot, R. R., and Mohutsky, M. (2010). Introduction to Hepatic Drug MetabolizingEnzyme Induction in Drug Safety Evaluation Studies. Toxicol Pathol 38, 796-798.

Rodricks, J. V., Swenberg, J. A., Borzelleca, J. F., Maronpot, R. R., and Shipp, A. M. Triclosan: A Critical Review of the Experimental Data and Development of Margins of Safety for Consumer Products. Crit Rev Toxicol 40, 422-484.

Calderon-Garciduenas, L., Franco-Lira, M., Henriquez-Roldan, C., Osnaya, N., Gonzalez-Maciel, A., Reynoso-Robles, R., Villarreal-Calderon, R., Herritt, L., Brooks, D., Keefe, S., Palacios-Moreno, J., Torres-Jardon, R., Medina-Cortina, H., Delgado-Chavez, R., Aiello-Mora, M., Maronpot, R. R., and Doty, R. L. (2010). Urban Air Pollution: Influences on Olfactory Function and Pathology in Exposed Children and Young Adults. Exp Toxicol Pathol 62, 91-102.

Ghosh, S., Hoenerhoff, M. J., Clayton, N., Myers, P., Stumpo, D. J., Maronpot, R. R., and Blackshear, P. J. Left-Sided Cardiac Valvulitis in Tristetraprolin-Deficient Mice: The role of Tumor Necrosis Factor Alpha. (2010). Am J Pathol 176, 1484-1493.

Branca, R. T., Cleveland, Z. I., Fubara, B., Kumar, C. S., Maronpot, R. R., Leuschner, C., Warren, W. S., and Driehuys, B. (2010). Molecular MRI for Sensitive and Specific Detection of Lung Metastases. Proc Natl Acad Sci, USA.

Arias-Loza, P. A., Muehlfelder, M., Elmore, S. A., Maronpot, R., Hu, K., Blode, H., Hegele-Hartung, C., Fritzemeier, K. H., Ertl, G., and Pelzer, T. (2009). Differential Effects of 17b -Estradiol and of Synthetic Progestins on Aldosterone-Salt InducedKidney Disease. Toxicol Pathol. Epub 2009/10/21.

Yoshizawa, K., Jelezcova, E., Brown, A. R., Foley, J. F., Nyska, A., Cui, X., Hofseth, L. J., Maronpot, R. M., Wilson, S. H., Sepulveda, A. R., and Sobol, R. W. (2009). Gastrointestinal Hyperplasia with Altered Expression of DNA Polymerase Beta. PLoS One 4, e6493.

Calderon-Garciduenas, L., Mora-Tiscareno, A., Gomez-Garza, G., Carrasco-Portugal Mdel, C., Perez- Guille, B., Flores-Murrieta, F. J., Perez-Guille, G., Osnaya, N., Juarez-Olguin, H., Monroy, M. E., Monroy, S., Gonzalez-Maciel, A., Reynoso-Robles, R., Villarreal-Calderon, R., Patel, S. A., Kumarathasan, P., Vincent, R., Henriquez-Roldan, C., Torres-Jardon, R., and Maronpot, R. R. (2009). Effects of a Cyclooxygenase-2 Preferential Inhibitor in Young Healthy Dogs Exposed to Air Pollution: A Pilot Study . Toxicol Pathol 37, 644-660.

Maronpot, R. R., Zeiger, E., McConnell, E. E., Kolenda-Roberts, H., Wall, H., and Friedman, M. A. (2009). Induction of Tunica Vaginalis Mesotheliomas in Rats by Xenobiotics. Crit Rev Toxicol 39, 512-537.

Calderon-Garciduenas, L., Franco-Lira, M., Henriquez-Roldan, C., Osnaya, N., Gonzalez-Maciel, A., Reynoso-Robles, R., Villarreal-Calderon, R., Herritt, L., Brooks, D., Keefe, S., Palacios-Moreno, J., Torres-Jardon, R., Medina-Cortina, H., Delgado-Chavez, R., Aiello-Mora, M., Maronpot, R. R., and Doty, R. L. (2009). Urban Air Pollution: Influences on Olfactory Function and Pathology in Exposed Children and Young Adults. Exp Toxicol Pathol. Epub 2009/03/20.

Moser, G. J., Foley, J., Burnett, M., Goldsworthy, T. L., and Maronpot, R. (2009). Furan-Induced Dose-Response Relationships for Liver Cytotoxicity, Cell Proliferation, and Tumorigenicity (Furan-InducedLliver Tumorigenicity). Exp Toxicol Pathol 61, 101-111.

Calderon-Garciduenas, L., Macias-Parra, M., Hoffmann, H. J., Valencia-Salazar, G., Henriquez-Roldan, C., Osnaya, N., Monte, O. C., Barragan-Mejia, G., Villarreal-Calderon, R., Romero, L., Granada-Macias, M., Torres-Jardon, R., Medina-Cortina, H., and Maronpot, R. R. (2009). Immunotoxicity and Environment: Immunodysregulation and Systemic Inflammation in Children. Toxicol Pathol 37, 161-169.

Murkunde, Y.V., Vijayamumar, K.S., Hemalatha, K., Maronpot, R.R., Herbert, R.A., Armstrong, J.M. and Wells, M.Y. (2008). Brain Lesion in a Wistar Rat. Lab Animal 37(9): 401-4.

Calderon-Garciduenas, L., Mora-Tiscareno, A., Ontiveros, E., Gomez-Garza, G., Barragan-Mejia, G., Broadway, J., Chapman, S., Valencia-Salazar, G., Jewells, V., Maronpot, R. R., Henriquez-Roldan, C., Perez-Guille, B., Torres-Jardon, R., Herrit, L., Brooks, D., Osnaya-Brizuela, N., Monroy, M. E., Gonzalez-Maciel, A., Reynoso-Robles, R., Villarreal-Calderon, R., Solt, A. C., and Engle, R. W. (2008). Air Pollution, Cognitive Deficits and Brain Abnormalities: A Pilot Study with Children and Dogs. Brain Cogn. 68(2): 117-27.

Dixon, D., Herbert R. A., Kissling, G.E., Brix, A.E., Miller, R.A. and Maronpot, R. R. (2008) Summary of chemically induced pulmonary lesions in the National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies. Toxicol Pathol 36: 428-39.

Guindon, K. A., Foley, J. F., Maronpot, R. R., and Massey, T. E. (2008). Failure of Catalase to Protect against Aflatoxin B(1)-Induced Mouse Lung Tumorigenicity. Toxicol Appl Pharmacol 227, 179-83.

Maronpot, R. R. (2006). Enhanced Histopathology of Lymphoid Tissues. Toxicol Pathol 34, 631-3.

Phillips, J. M., Yamamoto, Y., Negishi, M., Maronpot, R. R. and Goodman, J. I. (2007). Orphan Nuclear Receptor Constitutive Active/Androstane Receptor-Mediated Alterations in DNA Methylation during Phenobarbital Promotion ofLiver Tumorigenesis. Toxicol Sci. 96: 72-82.

Maronpot, R. R. (2006). A Monograph on Histomorphologic Evaluation of Lymphoid Organs. Toxicol Pathol 34, 407-8.

Cardiff, R. D., Anver, M. R., Boivin, G. P., Bosenberg, M. W., Maronpot, R. R., Molinolo, A. A., Nikitin, A.Y., Rehg, J. E., Thomas, G. V., Russell, R. G., and Ward, J. M. (2006). Precancer in Mice: Animal Models Used to Understand, Prevent, and Treat Human Precancers. Toxicol Pathol 34, 699-707.

Johnson, K., Ryan, L., Davis, J., Elmore, A., Guenther, B., Marcus, J., and Maronpot, R. R. (2006). Application of Magnetic Resonance Imaging in Developmental Neurotoxicity Testing: A Pilot Study. Neurotoxicology 27, 846-51.

Yamamoto, Y., Moore, R., Hess, H. A., Guo, G. L., Gonzalez, F. J., Korach, K. S., Maronpot, R. R., and Negishi, M . (2006). Estrogen Receptor Alpha Mediates 17Alpha -Ethynylestradiol-Causing Hepatotoxicity. J Biol Chem 281:16625-31.

Witschi, H., Espiritu, I., and Maronpot, R. R. (2005). Lung Tumors in 2-Year Old Strain A/J Mice
Exposed for 6 Months to Tobacco Smoke. Cancer Lett.Tam.

N. N., Nyska, A., Maronpot, R. R., Kissling, G., Lomnitski, L., Suttie, A., Bakshi, S., Bergman, M., Grossman, S., and Ho, S. M. (2006). Differential Attenuation of Oxidative/Nitrosative Injuries in Early Prostatic Neoplastic Lesions in TRAMP Mice by Eietary Antioxidants. Prostate 66, 57-69.

Tani, Y., Suttie, A., Flake, G. P., Nyska, A., and Maronpot, R. R. (2005). Epithelial-Stromal Tumor of the Seminal Vesicles in the Transgenic Adenocarcinoma MouseProstate Model. Vet Pathol 42,306-14.

Suttie, A. W., Dinse, G. E., Nyska, A., Moser, G. J., Goldsworthy, T. L., and Maronpot, R. R. (2005). An Investigation of the Effects of Late-Onset Dietary Restriction on Prostate Cancer Development in the TRAMP Mouse. Toxicol Pathol 33, 386-97.

Malarkey, D.E., Parker, J.S., Turman, C.A., Scott, A.M., Paules, R.S., Collins, J. and Maronpot, R. R. (2005). Microarray Data Analysis of Mouse Neoplasia. Toxicol. Pathol. 33: 127-135.

Malarkey, D.E., Johnson, K., Ryan, L., Boorman, G. and Maronpot, R. R. (2005). New Insights into Functional Aspects of Liver Morphology. Toxicol. Pathol. 33: 27-34.

Zhou, T., Jia, X., Chapin, R. E., Maronpot, R. R., Harris, M. W., Liu, J., Waalkes, M. P., and Eddy, E. M. (2004). Cadmium at a Non-Toxic Dose Alters Gene Expression in Mouse Testes. Toxicol Lett 154, 191-200.

Yamamoto, Y., Moore, R., Goldsworthy, T. L., Negishi, M., and Maronpot, R. R. (2004). The
Orphan Nuclear Receptor Constitutive Active/Androstane Receptor is Essential for Liver Tumor Promotion by Phenobarbital in Mice. Cancer Res 64, 7197-200.

Moyer, C., Allen, D., Basabe, A., Maronpot, R. R., and Nyska, A. (2004). Analysis of Vascular
Endothelial Growth Factor (VEGF) and a Receptor Subtype (KDR/flk-1) in the Liver of Rats Exposed to Riddeline: A Potential Role in the Development of Hemangiosarcoma. Exp Toxicol Pathol 55, 455-65.

Morgan, D. L., Little, P. B., Herr, D. W., Moser, V. C., Collins, B., Herbert, R., Johnson, G. A.,
Maronpot, R. R., Harry, G. J., and Sills, R. C. (2004). Neurotoxicity of Carbonyl Sulfide in F344
Rats Following Inhalation Exposure for up to 12 Weeks. Toxicol Appl Pharmacol 200, 131-45.

Maronpot, R. R., Sills, R. C., and Johnson, G. A. (2004). Applications of Magnetic Resonance Microscopy. Toxicol Pathol 32 Suppl 2, 42-8.

Calderon-Garciduenas, L., Reed, W., Maronpot, R. R., Henriquez-Roldan, C., Delgado-Chavez,
R., Calderon-Garciduenas, A., Dragustinovis, I., Franco-Lira, M., Aragon-Flores, M., Solt, A. C.,
Altenburg, M., Torres-Jardon, R., and Swenberg, J. A. (2004). Brain Inflammation and
Alzheimer’s-Like Pathology in Individuals Exposed to Severe Air Pollution. Toxicol Pathol 32, 650-8.

Stumpo, D. J., Byrd, N. A., Phillips, R. S., Ghosh, S., Maronpot, R. R., Castranio, T., Meyers, E. N., Mishina, Y., and Blackshear, P. J. (2004). Chorioallantoic Fusion Defects and Embryonic Lethality Resulting from Disruption of Zfp36L1, A Gene Encoding a CCCH Tandem Zinc Finger Protein of the Tristetraprolin Family. Mol Cell Biol 24, 6445-55.

Sills, R., Morgan, D., Herr, D., Little, P., George, N., Ton, T., Love, N., Maronpot, R., and Johnson, G. (2004). Contribution of Magnetic Resonance Microscopy in the 12-Week Neurotoxicity Evaluation of Carbonyl Sulfide in Fischer 344 Rats. Toxicol Pathol 32, 501-510.

Allen, D. G., Pearse, G., Haseman, J. K., and Maronpot, R. R. (2004). Prediction of Rodent Carcinogenesis: An Evaluation of Prechronic Liver Lesions as Forecasters of Liver Tumors in NTP Carcinogenicity Studies. Toxicol Pathol 32, 393-401.

Nyska, A., Haseman, J. K., Kohen, R., and Maronpot, R. R. (2004). Association ofLiver Hemangiosarcoma and Secondary Iron Overload in B6C3F1 Mice–the National Toxicology Program Experience. Toxicol Pathol 32, 222-8.

Nikitin, A. Y., Alcaraz, A., Anver, M. R., Bronson, R. T., Cardiff, R. D., Dixon, D., Fraire, A. E., Gabrielson, E. W., Gunning, W. T., Haines, D. C., Kaufman, M. H., Linnoila, R. I., Maronpot, R.
R., Rabson, A. S., Reddick, R. L., Rehm, S., Rozengurt, N., Schuller, H. M., Shmidt, E. N., Travis, W. D., Ward, J. M., and Jacks, T. (2004). Classification of Proliferative Pulmonary Lesions of the Mouse: Recommendations of the Mouse Models of Human Cancers Consortium. Cancer Res 64, 2307-16.

Maronpot, R. R., Flake, G., and Huff, J. (2004). Relevance of Animal Carcinogenesis Findings to Human Cancer Predictions and Prevention. Toxicol Pathol 32 Suppl 1, 40-8.

Herzog, C. R., Bodon, N., Pittman, B., Maronpot, R. R., Massey, T. E., Anderson, M. W., You, M., and Devereux, T. R. (2004). Carcinogen-Specific Targeting of Chromosome 12 for Loss of
Heterozygosity in Mouse Lung Adenocarcinomas: Implications for Chromosome Instability and Tumor Progression. Oncogene 23, 3033-9.

Hamadeh, H. K., Jayadev, S., Gaillard, E. T., Huang, Q., Stoll, R., Blanchard, K., Chou, J.,
Tucker, C. J., Collins, J., Maronpot, R., Bushel, P., and Afshari, C. A. (2004). Integration of
Clinical and Gene Expression Endpoints to Explore Furan-Mediated Hepatotoxicity. Mutat Res 549,169-83.

Tani, Y., Maronpot, R. R., Foley, J. F., Haseman, J. K., Walker, N. J., and Nyska, A. (2004).
Follicular Epithelial Cell Hypertrophy Induced by Chronic Oral Administration of 2,3,7,8-
Tetrachlorodibenzo-p-Dioxin in Female Harlan Sprague-Dawley Rats. Toxicol Pathol 32, 41-9.

Gallardo-Williams, M. T., Chapin, R. E., King, P. E., Moser, G. J., Goldsworthy, T. L., Morrison, J. P., and Maronpot, R. R. (2004). Boron Supplementation Inhibits the Growth and Local Expression of IGF-1 in Human Prostate Adenocarcinoma (LNCaP) Tumors in Nude Mice. Toxicol Pathol 32, 73-8.

Crissman, J. W., Goodman, D. G., Hildebrandt, P. K., Maronpot, R. R., Prater, D. A., Riley, J. H., Seaman, W. J., and Thake, D. C. (2004). Best Practices Guideline: Toxicologic Histopathology. Toxicol Pathol 32, 126-31.

Gallardo-Williams, M. T., Maronpot, R. R., Turner, C. H., Johnson, C. S., Harris, M. W., Jayo, M. J., and Chapin, R. E. (2003). Effects of Boric Acid Supplementation on Bone Histomorphometry, Metabolism, and Biomechanical Properties in Aged Female F-344 Rats. Biol Trace Elem Res 93, 155-70.

Calderon-Garciduenas, L., Maronpot, R. R., Torres-Jardon, R., Henriquez-Roldan, C., Schoonhoven, R., Acuna-Ayala, H., Villarreal-Calderon, A., Nakamura, J., Fernando, R., Reed,
W., Azzarelli, B., and Swenberg, J. A. (2003). DNA Damage in Nasal and Brain Tissues of Canines Exposed to Air Pollutants is Associated with Evidence of Chronic Brain Inflammation and Neurodegeneration. Toxicol Pathol 31, 524-38.

Gallardo-Williams, M. T., Maronpot, R. R., Wine, R. N., Brunssen, S. H., and Chapin, R. E. (2003). Inhibition of the Enzymatic Activity of Prostate-Specific Antigen by Boric Acid and 3-Nitrophenyl Boronic Acid. Prostate 54: 44-9.

Picut CA, Aoyama H, Holder JW, Gold LS, Maronpot RR and Dixon D. (2003). Bromoethane, Chloroethane and Ethylene Oxide Induced Uterine Neoplasms in B6C3F1 Mice from 2-Year
Inhalation Bioassyas: Pathology and Incidence Data Revisited. Exp Toxic Pathol 55: 1-9.

Gallardo-Williams MT, Maronpot RR, Turner CH, Johnson CS, Harris MW, Jayo MJ, Chapin RE. (2003). Effects of Boric Acid Supplementation on Bone Histomorphometry,Mmetabolism, and Biomechanical Properties in Aged Female F-344 Rats. Biol. Trace Element Res. 93: 155-169.

Nyska A, Suttie A, Bakshi S, Lomnitski L, Grossman S, Bergman M, Ben-Shaul V, Crocket P, Haseman JK, Moser G, Goldsworthy TL, and Maronpot RR. (2003). Slowing Tumorigenic
Progression in TRAMP Mice and Prostatic Carcinoma Cell Lines Using Natural Anti-Oxidant from Spinach, NAO–a Comparative Study of Three Anti-Oxidants. Toxicol Pathol 31: 39-51.

Ress NB, Hailey JR, Maronpot RR, Bucher JR, Travlos GS, Haseman JK, Orzech DP, Johnson JD and Hejtmancik MR. (2003). Toxicology and Carcinogenesis Studies of Microencapsulated Citral in Rats and Mice. Toxicol Sci 71: 198-206.

Tam AS, Devereux TR, Patel AC, Foley JF, Maronpot RR and Massey TR. (2003). Perturbations of the Ink4a/Arf Gene Locus in Aflatoxin B1-Induced Mouse lung Tumors. Carcinogenesis 24: 121-132.

Gallardo-Williams MT, Maronpot RR, Wine RN, Brunssen SH and Chapin RE. (2003). Inhibition of the Enzymatic Activity of Prostate-Specific Antigen by Boric Acid and 3-Nitrophenyl BoronicAacid. The Prostate 54:44-49.

Ma J, Bradbury JA, King L, Maronpot R, Davis LS, Breyer MD and Zeldin DC. (2002). Molecular Cloning and Characterization of Mouse CYP2J6, an Unstable Cytochrome P450 Isoform. Biochem Pharmacol 64:1447-1460.

Takahashi M, Dinse GE, Foley JF, Hardisty JF, and Maronpot RR. (2002). Comparative Prevalence, Multiplicity, and Progression of Spontaneous and Vinyl Carbamate-Induced Liver
Lesions in Five Strains of Male Mice. Toxicol Pathol 30: 599-605.
Johnson GA, Cofer GP, Fubara B, Gewalt SL, Hedlund LW, and Maronpot RR. (2002). Magnetic Resonance Histology for Morphologic Phenotyping. J Magn Reson Imaging 16: 423-9.

Okoji RS, Y RC, Maronpot RR and Froines JR. (2002). Sodium Arsenite Administration via Drinking Water Increases Genome-Wide and Ha-ras DNA Hypomethylation in Methyl-Deficient C57BL/6J mice. Carcinogenesis 23: 777-785.

Nyska A, Dayan A and Maronpot RR. (2002). New Tools in Therapeutic Research – Prostate Cancer and Models. Toxicol Pathol 30: 283-287.

Ozaki K, Haseman JK, Hailey JR, Maronpot RR and Nyska A. (2002). Association of Adrenal
Pheochhromocytoma andLlung Pathology in Inhalation Studies with Particulate Compounds in the Male F344 Rat – The National Toxicology Program experience. Toxicol Pathol 30: 263-270.

Suwa T, Nyska A, Haseman JK, Mahler JF and Maronpot RR. (2002). Spontaneous Lesions in
Control B6C3F1 Mice and Recommended Sectioning of Male Accessory Sex Organs. Toxicol Pathol 30: 228-234.

Gottschling BC, Maronpot RR, Hailey JR, Peddada S, Moomaw CR, Klaunig JE and Nska A. (2001). The Role of Oxidative Stress in IndiumPphosphide-Induced Lung Carcinogenesis in Rats. Toxicol Sci 64: 28-40.

Tsao C, Coulter SJ, Chien A, Luo G, Clayton N, Maronpot R, Goldstein JA and Zeldin DC. (2001). Identification and Localization of Five CYP2Cs in Murine Extrahepatic Tissues and Their Metabolism of Arachidonic Acid to Regio- and Stereoselective Products. J. Pharmacol. Exp. Therap. 299: 39-47.

Torres-Munoz J, Stockton P, Tacoronte N, Roberts B, Maronpot RR, and Petito CK. (2001).
Detection of HIV-1 Gene Sequences in Hippocampal Neurons Isolated from Postmortem AIDS Brains by Laser Capture Microdissection. J Neuropathol Exp Neurol 60: 885-92.

Hayashi S, Hong HH, Toyoda K, Ton TV, Devereux TR, Maronpot RR, Huff J, and Sills RC.
(2001). High Frequency of Rat Mutations in Rorestomach and Lung Tumors of B6C3F1 Mice
Exposed to 1-Amino-2,4-Dibromoanthraquinone for 2 Years. Toxicol Pathol 29: 422-9.

Johnson GA, Cofer GP, Hedlund LW, Maronpot RR and Suddarth SA. (2001). Registered 1H and 3He Magnetic Resonance Microscopy of the Lung. Magnetic Resonance in Med. 45: 365-370.

Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, and Zeldin DC. (2001). Cytochrome P450 CYP2J9, a New Mouse Arachidonic Acid Omega-1 Hydroxylase Predominately Expressed in Brain. J Biol Chem 27:27.

Nyska A, Lomnitski L, Maronpot R, Moomaw C, Brodsky B, Sintov A, and Wormser U. (2001). Effects of Iodine on InducibleNitric Oxide Synthase and Cyclooxygenase- 2 Expression in Sulfur Mustard-Induced Skin. Arch Toxicol 74: 768-74.
Suwa, T., Nyska, A, Haseman, JK, Mahler, JF and Maronpot, RR. (2001). Spontaneous Lesions in Control B6C3F1 Mice and Recommended Section of Male Accessory Sex Organs. Toxicol. Pathol.30:228-234.

Suwa, T., Nyska, A., Peckham, JC, Hailey, JR, Mahler, JF, Haseman, JK and Maronpot, RR.
(2001). A Retrospective Analysis of Background Lesions and Tissue Accountabiity for Male Accessory Sex Organs in Fischer-344 Rats. Toxicol. Pathol. 29: 467-478.

Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, and Goldstein JA. (2000). CYP2C40, a Unique Arachidonic Acid 16-Hydroxylase, is the Major CYP2C in Murine Intestinal Tract. Mol Pharmacol. 58: 279-287.

Sabo T, Lomnitski L, Nyska A, Beni S, Maronpot RR, Shohami E, Roses AD, and Michaelson DM. (2000). Susceptibility of Transgenic Mice Expressing Human Apolipoprotein E to Closed Head Injury: The Allele E3 is Neuroprotective Whereas E4 Increases Fatalities. Neuroscience. 101: 879-884.

Maronpot RR, Mitsumori K, Mann P, Takaoka M, Yamamoto S, Usui T, Okamiya H, Nishikawa S, and Nomura T. (2000). Interlaboratory Comparison of the CB6F1-Tg rasH2 Rapid Carcinogenicity Testing Model. Toxicology. 146: 149-159.

Lomnitski L, Nyska A, Ben-Shaul V, Maronpot RR, Haseman JK, Harrus TL, Bergman M, and
Grossman S. (2000). Effects of Antioxidants Apocynin and the Natural Water-Soluble Antioxidant from Spinach on Cellular Damage Induced by Lipopolysaccaride in the Rat. Toxicol Pathol. 28: 580-587.

Lomnitski L, Carbonatto M, Ben-Shaul V, Peano S, Conz A, Corradin L, Maronpot RR, Grossman S, and Nyska A. (2000). The Prophylactic Effects of Natural Water-Soluble Antioxidant from Spinach and Apocynin in a Rabbit Model of Lipopolysaccharide-Induced Endotoxemia. Toxicol Pathol. 28:588-600.

Liomnitski L, Foley JF, Grossman S, Shaul VB, Maronpot RR, Moomaw CR, Carbonatto M and
Nyska A. (2000). Effects of Apocynin and Natural Antioxidant from Spinach on Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Induction in Lipoipolysaccharide-Induced Hepatic Injury in Rat. Pharmacology & Toxicology 87: 18-25.

Chen XJ, Hedlund LW, Moller HE, Chawla MS, Maronpot RR and Johnson GA. (2000). Detection of Emphysema in Rat Lungs by Using Magnetic Resonance Measurements of 3He Diffusion. PNAS 97:11478-11481.

Maronpot RR, Mitsumori K, Mann P, Takaoka M, Yamamoto S, Usui T, Okamiya H, Nishikawa S and Nomura T. (2000). Interlaboratory Comparison of the CB6F1-Tg rasH2 Rapid Carcinogenicity Testing Model. Toxicology 146: 149-159.

Maronpot RR. (2000). The Use of Genetically Modified Animals in Carcinogenicity Bioassays. Toxicol. Pathol. 28: 450-453.

Long PH, Maronpot RR, Ghanayem BI, Roycroft JH and Myska A. (2000). Dental Pulp Infarction in Female Rats Following Inhalation Exposure to 2-Butoxyethanol. Toxicol. Pathol. 28: 246-252.

Ma J, Qu W, Scarborough PE, Tomer KB, Moomaw CR, Maronpot, R, Davis LS, Breyer MD and
Zeldin DC. (1999). Molecular Cloning, Enzymatic Characterization, Developmental Expression, and Cellular Localization of a Mouse Cytochrome P450 Highly Expressed in Kidney. J. Biol. Chem. 274:17777-17788.

Witschi H, Espirtu I, Pinkerton KE, Murphy K and Maronpot RR. 1999. Ozone Carcinogenesis Revisited. Toxicol. Sci. 52: 162-167.

Nyska A, Maronpot RR and Ghanayem BI. (1999). Ocular Thrombosis and Retinal Degeneration Induced in Female F344 Rats by 2-Butoxyethanol. Human & Experimental Toxicology 18: 577-582.

Tam AS, Foley JF, Devereux TR, Maronpot RR and Massey TE. (1999). High Frequency and
Heterogeneous Distribution of p53 Mutations in Aflatoxin B1-induced Mouse Lung Tumors. Cancer Res. 59: 3634-3640.

Levin S, Bucci TJ, Cohen SM, Fix AS, Hardisty JF, LeGrand EK, Maronpot RR and Trump BF.
(1999). The Nomenclature of Cell Death: Recommendations of an ad hoc Committee of the Society of Toxicologic Pathologists. Toxicol. Pathol. 27: 484-490.

Nyska A, Haseman JK, Hailey JR, Smetana S and Maronpot RR. (1999). The Association Between Severe Nephropathy and Pheochromocytoma in the Male F344 Rat – The National Toxicology Program Experience. Toxicol. Pathol. 27: 456-462.

Goldsworthy SM, Stockton PS, Trempus CS, Foley JF and Maronpot RR. (1999). Effects of Fixation on RNA Extraction and Amplification from Laser Capture Microdissected Tissue. Mol. Carc. 25:86-91.

Johnson J, Murray PK and Maronpot RR. (1999). Improved Method for Ultrastructural Preservation of Saccharomyces cerevisiae JHY-31-11D. Applied Immunohistochem and Molecular Morphology 7: 81-86.

Chhabra RS, Maronpot, RR, Bucher, JR, Haseman, JK, Toft, JD and Hejtmancik, MR. (1999).
Toxicology and Carcinogenesis Studies of Pentachlorophenol in Rats. Toxicol. Sci. 48: 14-20.

Nyska A, Maronpot RR, Long PH, Roycroft JH, Hailey JR, Travlos GS and Ghanayem BI. (1999). Disseminated Thrombosis and Bone Infarction in Female Rats Following Inhalation Exposure to 2-Butoxyethanol. Toxicol. Pathol. 27: 21-28.

Hailey JR, Haseman JK, Bucher JR, Radovsky AE, Malarkey DE, Miller RT, Nyska A and Maronpot RR. (1998). Impact of Helicobacter hepaticus Infection in B6C3F1 Mice from Twelve National Toxicology Program Two-Year Carcinogenesis Studies. Toxicol. Pathol. 26: 602-611.

Enomoto A, Sandgren EP and Maronpot RR. (1998). Altered Differentiation of Hepatocytes in a Transgenic Mouse Model of Hepatocarcinogenesis. Toxicol. Pathol. 26: 570-578.

Maronpot RR. (1998). The Potential of Genetically Altered Mice as Animal Models for Carcinogen Identification. Toxicol. Pathol. 26: 579-581.

Nyska A, Leininger JR, Maronpot RR, Haseman JK, and Hailey JR, (1998). Effect of individual versus group caging on the incidence of pituitary and Leydig cell tumors in F344 rats: proposed mechanism. Med Hypotheses. 50: 525-529.

Dragan Y, Klaunig J, Maronpot R, and Goldsworthy T. (1998). Mechanisms of susceptibility to mouse liver carcinogenesis. Toxicol Sci. 41: 3-7.

Enomoto A, Sandgren EP and Maronpot, RR. (1998). Interactive Effects of c-myc and Transforming Growth Factor a Transgenes on Liver Tumor Development in Simian Virus 40 T Antigen Transgenic Mice. Vet. Pathol. 35: 283-291.

Nyska A, Leininger JR, Maronpot RR, Haseman JK and Hailey JR. 1998. Effect of Individual Versus Group Caging on the Incidence of Pituitary and Leydig Cell Tumors in F344 Rats: Proposed Mechanism. Med. Hypotheses 50: 525-529.

Delnomdedieu M, Hedlund LW, Maronpot RR and Johnson GA. (1998). Magnetic Resonance Microscopy and Histopathology: Comparative Approach of Bromobenzene-Induced Hepatotoxicity in the Rat. Hepatology 27: 526-532.

Nyska A, Maronpot RR, Eldridge SR, Haseman JK and Hailey JR. (1997). Alteration in Cell Kinetics in Control B6C3F1 Mice Infected withHhelicobacter Hepaticus. Toxicol. Pathol. 25: 591-596.

Ton, TT, Foley, JF, Flagler, ND, Gaul, BW and Maronpot, RR. (1997). Feasibility of Administering 5-Bromo-2’-Deoxyuridine (BRDU) in Drinking Water for Labeling S-Phase Hepatocytes in Rats and Mice. Toxicol. Methods 7: 123-136.

Witschi, H, Espiritu, I, Maronpot, RR, Pinkerton, KE and Jones, AD. (1997). The Carcinogenic Potential of the Gas Phase of Environmental Tobacco Smoke. Carcinogenesis 18: 2035-2042.

Mitsumori, K, Wakana, S, Yamamoto, S, Kodama, Y, Yasuhara, K, kNomura, T, Hayashi, Y and
Maronpot, RR. (1997). Susceptibility of Transgenic Mice Carrying Human Prototype C-Ha-Ras Gene in a Short-Term Carcinogenicity Study of Vinyl Carbamate and Ras Gene Analyses of the Induced Tumors. Molecular Carcinogenesis 20: 298-307.

Kim, T-W, Porter, KL, Foley, JF, Maronpot, RR and Smart, RC. (1997). Evidence that Mirex Promotes a Unique Population of Epidermal Cells that Cannot be Distinguished by their Mutant Haras Genotype. Mol. Carcinogenesis 20: 115-124.

Witschi H, Espiritu I, Peake JL, Wu K, Maronpot RR, and Pinkerton KE. (1997). The Carcinogenicity of Environmental Tobacco Smoke. Carcinogenesis. 18: 575-586.
Maronpot RR. (1997). Comments on the Medium-Term Rat Liver Focus Bioassay. Toxicol Pathol. 25:461.

Carthew P, Maronpot RR, Foley JF, Edwards RE, and Nolan BM. (1997). Method for Determining Whether the Number of Hepatocytes in Rat Liver is Increased after Treatment with the Peroxisome Proliferator Gemfibrozil. J Appl Toxicol. 17: 47-51.

Romach, EH, Goldsworthy, TL, Maronpot, RR and Fox, TR. (1997). Altered Gene Expression in Spontaneous Hepatocellular Carcinomas from Male B6C3F1 Mice. Mol. Carcinogenesis 19: 31-38.

Johansson, E, Reynolds, S, Anderson, M and Maronpot, R. (1997). Frequency of Ha-ras-1 Gene Mutations Inversely Correlated with Furan Dose in Mouse Liver Tumors. Mol. Carcinogenesis 18:199-205.

Fransson-Steen, R, Goldsworthy, TL, Kedderis, GL and Maronpot, RR. (1997). Furan-Induced Liver Cell Proliferation and Apoptosis in Female B6C3F1 Mice. Toxicology 118: 195-204.

Witschi, H, Espiritu, I, Peake, JL, Wu, K, Maronpot, RR and Pinkerton, KE. (1997). The
Carcinogenicity of Environmental Tobacco Smoke. Carcinogenesis 18: 575-586.

Fox, TR, McMillen, PJ, Maronpot, RR and Goldsworthy, TL. 1997. Genomic Instability, as Measured by Microsatellite Alterations, Is Not Associated with Liver Tumor Development in the
Genetically Susceptible B6C3F1 Mouse. Toxocol. Appl. Pharmacol. 143: 167-172.

Davis, BJ, Almekinder, JL, Flagler, N, Travlos, G, Wilson, R, and Maronpot, RR. (1997). Ovarian Luteal Cell Toxicity of Ethylene Glycol Monomethyl Ether and Methoxy Acetic Acid in Vivo and in Vitro. Toxicol. Appl. Pharmacol. 142: 328-337.

Kong, L-Y, McMillian, MK, Maronpot, R, Hong, J-S. (1996). Protein Tyrosine Kinase Inhibitors Suppress the Production of Nitric Oxide in Mixed Glia, Microglia-Enriched or Astrocyte-Enriched Cultures. Brain Res. 729: 102-109.

Albert, RE, French, JF, Maronpot, R, Spalding, J and Tennant, R. (1996). Mechanisms of Skin
Tumorigenesis by Contact Sensitizers: The Effect of the Corticosteroid Fluocinolone Acetonide on Inflammation and Tumor Induction by 2,4 Dinitro-1-Fluorobenzene in the Skin of the TG.AC (v-Haras) Mouse. Environ. Hlth. Persp. 104: 1062-1068.

Donnelly, PJ, Devereux, TR, Foley, JF, Maronpot, RR, Anderson, MW and Massey, TE. (1996).
Activation of K-ras in Aflatoxin B1-Induced Lung Tumors from AC3F1 (A/J x C3H/HeJ) Mice.
Carcinogenesis 17: 1735-1740.

Carthew P, Maronpot RR, Foley J, Edwards, RE and Dorman,BM. (1996). A Method for Determining Whether the Number of Hepatocytes in Rat Liver is Increased after Treatment with the Peroxisome Proliferator Gemfibrozil. J. Appl. Toxicol. 17: 47-51.

Maronpot RR and Boorman GA. (1996). The Contribution of the Mouse in Hazard Identification Studies. Tox. Path. 24: 726-733.

Maronpot RR. (1996). A Symposium Summary and Perspective on Comparative Molecular Biology of Cancer. Tox. Path. 24: 801-804.

Mahler JF, Stokes W,Mann PC,Takaoka M and Maronpot RR. (1996). Spontaneous Lesions in Aging FVB/N Mice. Tox. Path. 24: 710-716.

Maronpot RR. (1996). Editorial. Laboratory Animal Pathology – Emphasis on an Area of Relevance to the Toxicologic Pathologist. Tox. Path. 24: 506.

Portier CJ, Sherman CD, Kohn M, Edler L, Kopp-Schneider A, Maronpot RR and Lucier G, (1996). Modeling the Number and Size of Hepatic Focal Lesions Following Exposure to 2,3,7,8-TCDD. Toxicol. Appl. Pharmacol. 138:20-30.

Delnomdedieu M, Hedlund LW, Johnson GA, and Maronpot RR. (1996). Magnetic Resonance
Microscopy — A New Tool for the Toxicologic Pathologist. Tox. Path. 24:36-44.

Goldsworthy TL, Fransson-Steen R, and Maronpot RR. (1996). Importance of and Approaches to Quantification of Hepatocyte Apoptosis. Tox. Path. 24:24-35.

Malarkey DE and Maronpot RR. (1996). Polymerase Chain Reaction and in situ Hybridization:
Applications in Toxicological Pathology. Tox. Path. 24:13-23.

Tritscher AM, Clark GC, Sewall CS, Sills RC, Maronpot R, and Lucier GW. (1995). Persistence of TCDD-Induced Hepatic Cell Proliferation and Growth of Enzyme Altered Foci after Chronic
Exposure Followed by Cessation of Treatment in DEN Initiated FemaleRrats. Carcinogenesis 16:2807-2811.

Zhou X, Maronpot RR, Hedlund LW, Cofer GP, and Johnson GA. (1995). Detection of
Bromobenzene-Induced Hepatocellular Necrosis Using Magnetic Resonance Microscopy. Magnetic Resonance in Medicine 34:853-857.

Liu J, Phillips KW, Foley JF, and Maronpot RR. (1995). Optimizing in Situ Hybridization of Lactoferrin mRNA in Mouse Uterine Tissue Using Digoxigenin-Labeled RNA Probes. Cell Vision 2:430-434.

Malarkey DE, Devereux TR, Dinse GE, Mann PC, and Maronpot RR. (1995). Hepatocarcinogenicity of Chlordane in B6C3F1 and B6D2F1 Male Mice: Evidence for Regression in B6C3F1 Mice and Carcinogenesis Independent of ras Proto-oncogene Activation. Carcinogenesis 16:2617-2625.

Maronpot RR, Devereux TR, Hegi M, Foley JF, Kanno J, Wiseman R, and Anderson MW. (1995). Hepatic and Pulmonary Carcinogenicity of Methylene Chloride in Mice: A Search for Mechanisms. Toxicology 102:73-81.

Takahashi K, Vivano CJ, Elwell MR, Bakewell WE, Kuwahara M, Nakashima N, Blackwell BN, and Maronpot RR. (1995). Bile Duct-Specific Lectins, Dolichos Biflorus Agglutinin and Peanut Agglutinin, as Probes in Mouse Hepatocarcinogenesis. Laboratory Investigation 73:424-432.

Massey TE, Devereux TR, Maronpot RR, Foley JF, and Anderson MW. (1995). High Frequency of Kras Mutations in Spontaneous and Vinyl Carbamate-induced Lung Tumors of Relatively Resistant B6CF1 (C57BL/6J x BALB/cJ) Mice. Carcinogenesis 16:1065-1069.

Maronpot RR, Fox T, Malarkey DE, and Goldsworthy TL. (1995). Mutations in the ras Protooncogene: Clues to Etiology and Molecular Pathogenesis of Mouse Liver Tumors. Toxicology 101:125-156.

Watson MA, Devereux TR, Malarkey DE, Anderson MW, and Maronpot RR. (1995). H-ras Oncogene Mutation Spectra in B6C3F1 and C57BL/6 Mouse Liver Tumors Provide Evidence for TCDD Promotion of Spontaneous and Vinyl Carbamate-initiated Liver Cells. Carcinogenesis 16:1705-1710.

Ton TT, Elwell MR, Morris RW, and Maronpot RR, (1995). Development and Persistence of
Placental Glutathione-S-Transferase-Positive Foci in Livers of Male F344 Rats Exposed to o-
Nitrotoluene. Cancer Ltrs. 95:167-173.

Sewall CH, Flagler N, Vanden Heuvel JP, Clark GC, Tritscher AM, Maronpot RR, and Lucier GW. (1995). Alterations in Thyroid Function in Female Sprague-Dawley Rats Following Chronic Treatment with 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Tox. & Appl. Pharmacol. 132:237-244.

Davis LM, Caspary WJ, Sakallah SA, Maronpot R, Wiseman R, Barrett JC, Elliott R, and Hozier J. (1994). Loss of Heterozygosity in Spontaneous and Chemically Induced Tumors of the B6C3F1 Mouse. Carcinogenesis 15:1637-1645.

Devereux TR, Wiseman RW, Kaplan N, Garren S, Foley JF, White CM, Anna C, Watson MA, Patel A, Jarchow S, Maronpot RR, and Anderson MW. (1994). Assignment of a Locus for Mouse Lung Tumor Susceptibility to Proximal Chromosome 19. Mammalian Genome 5:749-755.

Hegi ME, Devereux TR, Dietrich WF, Cochran CJ, Lander ES, Foley JF, Maronpot RR, Anderson MW, and Wiseman RW. (1994). Allelotype Analysis of Mouse Lung Carcinomas Reveals Frequent Allelic Losses on Chromosome 4 and an Association Between Allelic Imbalances on Chromosome 6 and K-ras Activation. Cancer Res. 54:6257-6264.

Goodrow TL, Nichols WW, Storer RD, Anderson MW, and Maronpot RR. (1994). Activation of H-ras is Prevalent in 1,3-Butadiene-induced and Spontaneously Occurring Murine Harderian Gland Tumors. Carcinogenesis 15:2665-2667.

Davis BJ, Maronpot RR, and Heindel JJ. (1994). Di-(2-ethylhexyl) Phthalate Suppresses Estradiol and Ovulation in Cycling Rats. Tox. & Appl. Pharmacol. 128:216-223.

Anna CH, Maronpot RR, Pereira MA, Foley JF, Malarkey DE, and Anderson MW. (1994). Ras Protooncogene Activation in Dichloroacetic acid-, Trichloroethylene-,and Tetrachloroethylene-induced Liver Tumors in B6C3F1 Mice. Carcinogenesis 15:2255-2261.

Preston GA, Lang JE, Maronpot RR, and Barrett JC. (1994). Regulation of Apoptosis by Low Serum in Cells of Different Stages of Neoplastic Progression: Enhanced Susceptibility After Loss of a Senescence Gene and Decreased Susceptibility After Loss of a Tumor Suppressor Gene. Cancer Res. 54:4214-4223.

Stanley LA, Blackburn DR, Devereaux S, Foley J, Lord PG, Maronpot RR, Orton TC, and Anderson MW. (1994). Ras Mutations in Methylclofenapate-induced B6C3F1 and C57BL/10J Mouse Liver Tumours. Carcinogenesis 15:1125-1131.

Boorman GA, Maronpot RR, and Eustis SL. (1994). Rodent Carcinogenicity Bioassay: Past, Present, and Future. Tox. Path. 22:105-111.

Zhou X, Maronpot RR, Mills GI, Cofer GP, Hedlund LW and Johnson GA. (1994). Studies on Bromobenzene-induced Hepatotoxicity Using in vivo MR Microscopy with Surgically Implanted RF Coils. Magnetic Resonance in Medicine 31:619-627.

Devereux TR, White CM, Sills RC, Bucher JR, Maronpot RR, and Anderson MW. (1994). Low Frequency of H-ras Mutations in Hepatocellular Adenomas and Carcinomas and in Hepatoblastomas from B6C3F1 Mice Exposed to Oxazepam in the Diet. Carcinogenesis 15:1083-1087.

Dixon D, Yoshitomi K, Boorman GA, and Maronpot RR. (1994). “Lipomatous” Lesions of Unknown Cellular Origin in the Liver of B6C3F1 Mice. Vet. Path. 31:173-182.

Cunningham ML, Maronpot RR, Thompson M, and Bucher JR. (1994). Early Responses of the Liver of B6C3F1 Mice to the Hepatocarcinogen Oxazepam: Tox. & Appl. Pharmacol. 124:31-38.

Herzog CR, Schut HAJ, Maronpot RR, and You M. (1993). Ras Mutations in 2-amino-3-methylimidazo[4,5-f]quinoline-induced Tumors from the CDF1 Mouse. Molecular Carcinogenesis 8:202-207.

Takahashi K, Lindamood III C, and Maronpot RR. (1993). Retrospective Study of Possible a-2mglobulin Nephropathy and Associated Cell Proliferation in Male Fischer 344 Rats Dosed with T-Butyl Alcohol. EHP 101:281-286.

Ghanayem BI, Sanchez IM, Maronpot RR, Elwell MR, and Matthews HB. (1993). Relationship Between the Time of Sustained Ethyl Acrylate Forestomach Hyperplasia and Carcinogenicity. EHP 101:277-280.

Kanno J, Foley JF, Kari F, Anderson MW, and Maronpot RR. (1993). Effect of Methylene Chloride Inhalation on Replicative DNA Synthesis in the Lungs of Female B6C3F1 Mice. EHP 101:271-276.
Greenwell A, Foley JF, and Maronpot RR. (1993). Detecting Proliferating Cell Nuclear Antigen in Archival Rodent Tissues. EHP 101:207-209.

Foley J, Ton T, Maronpot R, Butterworth B, and Goldsworthy TL. (1993). Comparison of Proliferating Cell Nuclear Antigen to Tritiated Thymidine as a Marker of Proliferating Hepatocytes in Rats. EHP 101:199-205.

Goldsworthy TL, Butterworth BE, and Maronpot RR. (1993). Concepts, Labeling Procedures, and Design of Cell Proliferation Studies Relating to Carcinogenesis. EHP 101:59-65.

Melnick RL, Huff J, Barrett JC, Maronpot RR, Lucier G, and Portier CJ. (1993). Cell Proliferation and Chemical Carcinogenesis: Symposium Overview. EHP 101:3-5.

Kanno J, Maronpot RR, Takahashi M, Kasuga T, and Hayashi Y. (1993). Regressive and Nonregressive Thyroid Lesions of the Rat Induced by Single Injection of N-bis(2-hydroxypropyl)
nitrosamine and Iodine Deficient Diet. Carcinogenesis 14:2389-2396.

Johnson GA, Benveniste H, Black RD, Hedlund LW, Maronpot RR, and Smith BR. (1993). Histology by Magnetic Resonance Microscopy. Magnetic Resonance Quarterly 1993; 9(1):1-30.

Maronpot RR, Foley JF, Takahashi K, Goldsworthy T, Clark G, Tritscher A, Portier C, and Lucier G. (1993). Dose Response for TCDD Promotion of Hepatocarcinogenesis in Rats Initiated with DEN: Histologic, Biochemical, and Cell Proliferation Endpoints. EHP 101:634-642.

Devereux TR, Belinsky SA, Maronpot RR, White CM, Hegi ME, Patel AC, Foley JF, Greenwell A, and Anderson MW. (1993). Comparison of Pulmonary 06-methylguanine DNA Adduct Levels and Kiras Activation in Lung Tumors from Resistant and Susceptible Mouse Strains. Molecular Carcinogenesis 8:177-185.

Chen B, Liu L, Castonguay A, Maronpot RR, Anderson MW, and You M. (1993). Dose-dependent ras Mutation Spectra in N- nitrosodiethylamine-induced Mouse Liver Tumors and 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone Induced Mouse Lung Tumors. Carcinogenesis 14:1603-1608.

Kari FW, Foley JF, Seilkop SK, Maronpot RR, and Anderson MW. (1993). Effect of Varying Exposure Regimens on Methylene Chloride-induced Lung and Liver Tumors in Female B6C3F1 Mice. Carcinogenesis 14:819-826.

Foley JF, Tuck PD, Ton TVT, Frost M, Kari F, Anderson M.W, and Maronpot RR. (1993). Inhalation Exposure to a Hepatocarcinogenic Concentration of Methylene Chloride Does Not Induce Sustained Replicative DNA Synthesis in Hepatocytes of Female B6C3F1 Mice. Carcinogenesis 14:811-818.

Hegi ME, Soderkvist P, Foley JF, Schoonhoven R, Swenberg JA, Kari F, Maronpot R, Anderson MW, and Wiseman RW. (1993). Characterization of p53 Mutations in Methylene Chloride-induced Lung Tumors from B6C3F1 Mice. Carcinogenesis 14:803-810.

Devereux TR, Foley JF, Maronpot RR, Kari F, and Anderson MW. (1993). Ras Proto-oncogene Activation in Liver and Lung Tumors from B6C3F1 Mice Exposed Chronically to Methylene Chloride. Carcinogenesis 14:795-802.

Anderson MW and Maronpot RR. (1993). Editorial: Methylene Chloride-induced Tumorigenesis. Carcinogenesis 14:787-788.

Melnick RL, Huff J, Barrett JC, Maronpot RR, Lucier G, and Portier CJ. (1993). Cell Proliferation and Chemical Carcinogenesis: A Symposium Overview. Molecular Carcinogenesis 7:135-138.

Cullen JM, Sandgren EP, Brinster RL, and Maronpot RR. (1993). Histologic Characterization of
Hepatic Carcinogenesis in Transgenic Mice Expressing SV40 T-antigens. Vet. Path. 30:111-118.

Anderson MW, Reynolds SH, You M, and Maronpot RR. (1992). Role of Proto-oncogene Activation in Carcinogenesis. EHP 98:13-24.

Stanley LA, Devereux TR, Foley J, Lord PG, Maronpot RR, Orton TC, and Anderson MW. (1992). Proto-oncogene Activation in Liver Tumors of Hepatocarcinogenesis-resistant Strains of Mice. Carcinogenesis 13:2427-2433.

Takahashi K, Maita K, Kuwahara M, Harada T, and Maronpot RR. (1992). Eosinophilic Globule Cells in Mouse MFH-like Sarcomas: Lectin Histochemistry. Virchows Archiv B Cell Pathol. 62:89-95.

Dragan YP, Xu YH, Goldsworthy TL, Campbell HA, Maronpot RR, and Pitot HC. (1992).
Characterization of the Promotion of Altered Hepatic Foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Female Rat. Carcinogenesis 13:1389-1395.

Xu YH, Dragan YP, Maronpot RR, Goldsworthy TL, and Pitot HC. (1992). Criteria, Mechanisms, and Potency Evaluation for Tumor Promoters: Dioxin as a Model. Chemosphere 25:227-230.

Lucier GW, Clark G, Tritscher A, Foley J, and Maronpot R. (1992). Mechanisms of Dioxin Tumor Promotion – Implications for Risk Assessment. Chemosphere 25:177-180.

Dieter MP, Maronpot RR, Jameson CW, and Ward SM. (1992). The Effects of Iodinated Glycerol, Trichlorfon, and Acetaminophen on Tumor Progression in a Fischer Rat Leukemia Transplant Model. Cancer Detection and Prevention 16:173-183.

You M, Wang Y, Stoner G, You L, Maronpot R, Reynolds S, and Anderson M. (1992). Parental Bias of Ki-ras Oncogenes Detected in Lung Tumors from Mouse Hybrids. Proc. Natl. Acad. Sci, USA 89:5804-5808.

Lindamood III C, Farnell DR, Giles HD, Prejean JD, Collins JJ, Takahashi K, and Maronpot RR, (1992). Subchronic Toxicity Studies of t-butyl Alcohol in Rats and Mice. Fund. & Appl. Tox. 19:91-100.

Belinsky SA, Devereux TR, Foley JF, Maronpot RR, and Anderson MW. (1992). Role of the Alveolar type-II Cell in the Development and Progression of Pulmonary Tumors Induced by 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone in the A/J Mouse. Cancer Res. 52:3164-3173.

Whitehead Jr. RE, Sugawara O, Maronpot RR, Gladen BC, and Barrett JC. (1992). Detection of Multiple Tumor Suppressor Genes for Syrian Hamster Fibrosarcomas by Somatic Cell Hybridization. Somatic Cell and Molecular Genetics 18:131-142.

Ghanayem BI, Matthews HB, and Maronpot RR. (1991). Sustainability of Forestomach Hyperplasia in Rats Treated with Ethyl Acrylate for 13 Weeks and Regression After Cessation of Dosing. Tox. Path. 19:273-279.

Foley JF, Dietrich DR, Swenberg JA, and Maronpot RR. (1991). Detection and Evaluation of Proliferating Cell Nuclear Antigen (PCNA) in Rat Tissue by an Improved Immunohistochemical Procedure. The J. of Histotechnology 14:237-241.

Dixon D and Maronpot RR. (1991). Histomorphologic Features of Spontaneous and Chemicallyinduced Pulmonary Neoplasms in B6C3F1 Mice and Fischer 344 Rats. Tox. Path. 19:540-556.

Brown HR, Monticello TM, Maronpot RR, Randall HW, Hotchkiss JR, and Morgan KT. (1991).
Proliferative and Neoplastic Lesions in the Rodent Nasal Cavity. Tox. Path. 19:358-372.

Maronpot RR, Giles HD, Dykes DJ, and Irwin RD. (1991). Furan-induced Hepatic Cholangiocarcinomas in Fischer 344 Rats. Tox. Path. 19:561-570.

Dixon D, Marshall KLE, Greenwell A, Shimizu T, Nettesheim P, and Maronpot RR. (1991).
Comparison of Automated and Manual Staining Techniques for the Binding of Wheat Germ
Agglutinin (WGA) in Modified B5- and Formalin-fixed Pulmonary Tissue. The J. of Histotechnology 14:149-153.

Greenwell A, Foley J.F, and Maronpot RR. (1991). An Enhancement Method for Immunohistochemical Staining of Proliferating Cell Nuclear Antigen in Archival Rodent Tissues. Cancer Ltrs. 59:251-256.

Candrian U, You M, Goodrow T, Maronpot RR, Reynolds SH, and Anderson MW. (1991). Activation of Protooncogenes in Spontaneously Occurring non-Liver Tumors from C57BL/6 x C3H F1 Mice. Cancer Res. 51:1148-1153.

Hedlund LW, Maronpot RR, Johnson GA, Cofer GP, Mille GM, and Wheeler CT. (1991). Magnetic Resonance Microscopy of Toxic Renal Injury Induced by Bromoethylamine in Rats. Fund. & Appl. Tox. 16:787-797.

Blair PC, Thompson MB, Wilson RE, Esber HH, and Maronpot RR. (1991). Correlation of Changes in Serum Analytes and Hepatic Histopathology in Rats Exposed to Carbon Tetrachloride. Tox. Ltrs. 55:149-159.

Ghanayem BI, Maronpot RR, and Matthews HB. (1991). Effects of Sulfhydryl Modulation on Ethyl Acrylate-induced Forestomach Toxicity. Tox. Ltrs. 55:215-221.

Maronpot RR. (1991). Correlation of Data from the Strain A Mouse Bioassay with Long-term Bioassays. Exp. Lung Res. 17:425-431.

You M, Wang Y, Lineen A, Stoner GD, You L, Maronpot RR, and Anderson MW. (1991). Activation of Protooncogenes in Mouse Lung Tumors. Exp. Lung Res. 17:389-400.

Maronpot RR, Palmiter RD, Brinster RL, and Sandgren EP. (1991). Pulmonary Carcinogenesis in Transgenic Mice. Exp. Lung Res. 17:305-320.

Belinsky SA, Devereux TR, White CM, Foley JF, Maronpot RR, and Anderson MW. (1991). Role of Clara Cells and Type II cells in the Development of Pulmonary Tumors in Rats and Mice Following Exposure to a Tobacco-specific Nitrosamine. Exp. Lung Res. 17:263-278.

Foley JF, Anderson MW, Stoner GD, Gaul BW, Hardisty JF, and Maronpot RR. (1991). Proliferative lesions of the Mouse Lung: Progression Studies in Strain A Mice. Exp. Lung Res. 17:157-168.

Dixon D, Horton J, Haseman JK, Talley F, Greenwell A, Nettesheim P, Hook GE, and Maronpot RR. (1991). Histomorphology and Ultrastructure of Spontaneous Pulmonary Neoplasms in Strain A Mice. Exp. Lung Res. 17:131-155.

Dragan YP, Rizvi T, Xu YH, Hully JR, Bawa N, Campbell HA, Maronpot RR, and Pitot HC. (1991). An Initiation-Promotion Assay in Rat Liver as a Potential Complement to the 2-year Carcinogenesis Bioassay. Fund. & Appl. Tox. 16:525-547.

Lucier GW, Trischer A, Goldsworthy T, Foley J, Clark G, Goldstein J, and Maronpot RR. (1991). Ovarian Hormones Enhance 2, 3, 7, 8- tetrachlorodibenzo-p-dioxin-mediated Increases in Cell Proliferation and Preneoplastic Foci in a Two-stage Model for Rat Hepatocarcinogenesis. Cancer Res. 51:1391-1397.

Cunningham ML, Foley J, Maronpot RR, and Matthews HB. (1991). Correlation of Hepatocellular Proliferation with Hepatocarcinogenicity Induced by the Mutagenic Noncarcinogen:Carcinogen pair – 2,6- and 2,4-diaminotoluene. Tox. & Appl. Pharmacol. 107:562-567.
Dittrich KL, Smith R, and Maronpot RR. (1990). Stability of Gamma-glutamyltranspeptidase (GGT) in Paraffin Embedded Liver Tissue. The J. of Histotechnology 13:185-187.

Harada T, Maronpot RR, Boorman GA, Morris RW, and Stitzel KA. (1990). Foci of Cellular Alteration in the Rat Liver: A Review. Tox. Path. 3:161-188.
Goodrow T, Reynolds S, Maronpot R, and Anderson M. (1990). Activation of K-ras by Codon 13 Mutations in C57BL/6 x C3H F1 Mouse Tumors Induced by Exposure to 1,3-butadiene. Cancer Res. 50: 4818-4823.

Belinsky SA, Foley JF, White KM, Anderson MW, and Maronpot RR. (1990). Dose-Response Relationship between O6-methylguanine Formation in Clara Cells and Induction of Pulmonary Neoplasia in the Rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res. 50: 3772-3780.

Maronpot RR. (1990). Pathology Working Group Review of Selected Upper Respiratory Tract Lesions in Rats and Mice. EHP 85: 331-352.

Uraih LC and Maronpot RR. (1990). Normal Histology of the Nasal Cavity and Application of Special Techniques. EHP 85: 187-208.

Dieter MP, Jameson CW, Maronpot RR, Langenbach R, and Braun AG. (1990). The Chemotherapeutic Potential of Glycol Alkyl Ethers: Structure- activity Studies of Nine Compounds in a Fischer Rat Leukemia Transplant Model. Cancer Chemo. & Pharmacol. 26: 173-180.

Xu YH, Maronpot RR, and Pitot HC. (1990). Quantitative Stereologic Study of the Effects of Varying the Time Between Initiation and Promotion on 4 Histochemical Markers in Rat-liver During Hepatocarcinogenesis. Carcinogenesis 11:267-272.

Xu YH, Campbell HA, Sattler GL, Hendrich S, Maronpot R, Sato K, and Pitot HC. (1990). Quantitative Stereological Analysis of the Effects of Age and Sex on Multistage Hepatocarcinogenesis in the Rat by Use of 4 Cytochemical Markers. Cancer Res. 50:472-479.
Harada T, Maronpot RR, Morris RW, and Boorman GA. (1990). Effects of Mononuclear Cell Leukemia on Altered Hepatocellular Foci in Fischer 344 Rats. Vet. Path. 27:110-116.

Campen D, Maronpot RR, and Lucier G. (1990). Dose-Response Relationships in Promotion of Rat Hepatocarcinogenesis by 17-a-ethinylestradiol. J. Tox. & Environ. Hlth. 29:257-268.

Reynolds SH, Patterson RM, Mennear JH, Maronpot RR, and Anderson MW. (1990). Ras Gene Activation in Rat Tumors Induced by Benzidine Congeners and Derived Dyes. Cancer Res. 50:266-272.

Harada T, Maronpot RR, Morris RW, and Boorman GA. (1989). Observations on Altered Hepatocellular Foci in National Toxicology Program Two-year Carcinogenicity Studies in Rats. Tox. Path. 17:690-708.

Maronpot RR, Harada T, Murthy ASK, and Boorman GA. (1989). Documenting Foci of Hepatocellular Alteration in Two-year Carcinogenicity Studies: Current Practices of the National Toxicology Program. Tox. Path. 17:675-684.

Maronpot RR, Pitot HC, and Peraino C. (1989). Use of Rat Liver Altered Focus Models for Testing Chemicals that have Completed Two-Year Carcinogenicity Studies. Tox. Path. 17:651-662.

Johnson, GA and Maronpot RR. (1989). Magnetic Resonance Microscopy of Chemically-Induced Liver Foci. Tox. Path. 17:613-616.

Pitot, HC, Campbell, HA, Maronpot R, Bawa N, Rizva TA, Xu Y, Sargent L, Dragan Y, and Pyron M. (1989). Critical Parameters in the Quantitation of the Stages of Initiation, Promotion, and Progression in One Model of Hepatocarcinogenesis in the Rat. Tox. Path. 17:594-612.

Harada T, Maronpot RR, Morris RW, Stitzel KA, and Boorman GA. (1989). Morphological and Stereological Characterization of Hepatic Foci of Cellular Alteration in Control Fischer 344 Rats. Tox. Path. 17:579-593.

Ulland BM, Maronpot RR, Lemen JK, and Mennear JH. (1989). Transplantation Studies of Preputial Gland and Epithelial Skin Neoplasms Derived from Benzidine-based Dye Carcinogenicity Assays in Fischer 344 Male Rats. Tox. Path. 17:50-56.

Belinsky SA, Devereux TR, Maronpot RR, Stoner GD, and Anderson MW. (1989). Relationship
between the Formation of Promutagenic Adducts and the Activation of the K-ras Protooncogene in Lung Tumors from A/J Mice Treated with Nitrosamines. Cancer Res. 49:5305-5311.

Huff JE, Haseman JK, Demarini DM, Eustis S, Maronpot RR, Peters AC, Persing RL, Chrisp CE, and Jacobs AC. (1989). Multiple-Site Carcinogenicity of Benzene in Fischer-344 Rats and B6C3F1 Mice. EHP 82:125-163.

Farmer THR, Johnson GA, Cofer GP, Maronpot RR, Dixon D, and Hedlund LW. (1989). Implanted Coil MR Microscopy of Renal Pathology. Magnetic Resonance in Medicine 10:310-323.

Johnson GA, Thompson MB, Cofer GP, Campen D, and Maronpot RR. (1989). Magnetic Resonance Imaging of Hepatic Neoplasms in the Rat. Vet. Path. 26:303-308.

You M, Candrian U, Maronpot RR, Stoner GD, and Anderson MW. (1989). Activation of the Ki-ras Protooncogene in Spontaneously Occurring and Chemically Induced Lung Tumors of the Strain A Mouse. Proc. Natl. Acad. Sci. 86:3070-3074.

Pitot HC, Goodspeed D, Dunn T, Hendrich S, Maronpot RR, and Moran S. (1989). Regulation of the Expression of Some Genes for Enzymes of Glutathione Metabolism in Hepatotoxicity and Hepatocarcinogenesis. Tox. & Appl. Pharmacol. 97:23-34.

Goldstein JA, Graham MJ, Sloop T, Maronpot RR, Goodrow T, and Lucier GW. (1989). Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Estradiol Metabolism, Enzyme-altered Foci in a Two Stage Hepatocarcinogenesis Model in Rats. Chemosphere 18:695-700.

Graham MJ, Lucier GW, Linko P, Maronpot RR, Goldstein JA. (1988). Increases in Cytochrome P-450 Mediated 17-b-Estradiol 2- Hydroxylase Activity in Rat Liver Microsomes after both Acute Administration and Subchronic Administration of 2,3,7,8-Tetrachlorodibenzo- p-dioxin in a Twostage Hepatocarcinogenesis Model. Carcinogenesis 9:1935- 1941.

Dixon D, Johnson GA, Cofer GP, Hedlund L.W, and Maronpot RR. (1988). Magnetic Resonance Imaging (MRI): A New Tool in Experimental Toxicologic Pathology. Tox. Path. 16:386-391.

Maronpot RR, Ulland B, and Mennear J. (1988). Transplantation Characteristics, Morphologic Features, and Interpretation of Preputial Gland Neoplasia in the Fischer-344 Rat. EHP 77:33-36.

Germolec DR, Maronpot RR, Ackermann MF, Vore SJ, Dittrich K, Rosenthal GJ, and Luster MI,
(1988). Lack of a Relationship Between Immune Function and Chemically Induced Hepatocarcinogenesis in B6C3F1 Mice. Cancer Immunology Immunotherapy 27:121-127.

Peraino C, Carnes BA, Stevens FJ, Staffeldt EF, Russell JR, Prapuolenis A, Blomquist JA, Vesselinovitch SD, and Maronpot RR. (1988). Comparative Developmental and Phenotypic Properties of Altered Hepatocyte Foci and Hepatic Tumors in Rats. Cancer Res. 48:4171-4178.

Belinsky SA, Dolan ME, White CM, Maronpot RR, Pegg AE, and Anderson MW. (1988). Cell Specific Differences in O6-Methylguanine- DNA Methyltransferase Activity and Removal of 06-
Methylguanine in Rat Pulmonary Cells. Carcinogenesis 9:2053-2058.

Hong HL, Huff JE, Luster MI, Maronpot RR, Dieter MP, Hayes HT, and Boorman GA. (1988). The Effects of Allyl Isovalerate on the Hematopoietic and Immunologic Systems in Rodents. Fund. & Appl. Tox. 10:655-663.

Reynolds SH, Stowers, SJ, Patterson RM, Maronpot RR, and Anderson MW. (1988). Oncogene Activation in Spontaneous and Chemically Induced Rodent Tumors: Implications for Risk Analysis. EHP 78:175-177.

Goering PL, Maronpot RR, and Fowler BA. (1988). Effect of Intratracheal Gallium Arsenide
Administration on d-Aminolevulinic Acid Dehydratase in Rats: Relationship to Urinary Excretion of Aminolevulinic Acid. Toxicol. Appl. Pharmacol. 92:179-193.

Pitot HC, Goldsworthy T, Moran S, Kennan W, Glauert H, Maronpot RR, and Campbell HA, (1987). A Method to Quantitate the Relative Initiating and Promoting Potencies of Hepatocarcinogenic Agents in Their Dose-Response Relationships to Altered Hepatic Foci. Carcinogenesis 8:1491-1499.

Stowers SJ, Maronpot RR, Reynolds SH, and Anderson MW. (1987). The Role of Oncogenes in Chemical Carcinogenesis. EHP 75:81-86.

Reynolds SH, Stowers SJ, Patterson RM, Maronpot RR, Aaronson SA, and Anderson MW, (1987). Activated Oncogenes in B6C3F1 Mouse Liver Tumors: Implications For Risk Assessment. Science 237:1309-1316.

Ghanayem BI, Blair P, Thompson MB, Maronpot RR, and Matthews HB. (1987). Effect of Age on the Toxicity and Metabolism of Ethylene Glycol Monobutyl Ether (2-Butoxyethanol) in Rats. Tox. & Appl. Pharmacol. 91:222-234.

Mitsumori K, Dittrich KL, Stefanski S, Talley FA, and Maronpot RR. (1987). Immunohistochemical and Electron Microscopic Study of Meningeal Granular Cell Tumors in Rats. Vet. Path. 24:356-359.

Belinsky SA, Walker VE, Maronpot RR, Swenberg JA, and Anderson MW. (1987). Molecular
Dosimetry of DNA Adduct Formation and Cell Toxicity in Rat Nasal Mucosa Following Exposure to the Tobacco Specific Nitrosamine (N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and their Relationship to Induction of Neoplasia. Cancer Res. 47:6058-6065.

Hsieh LL, Hsiao WL, Peraino C, Maronpot RR, and Weinstein IB. (1987). Expression of Retroviral Sequences and Oncogenes in Rat Liver Tumors Induced by Diethylnitrosamine. Cancer Res.47:3421-3424.

Stowers SJ, Glover PL, Reynolds SH, Boone LR, Maronpot RR, and Anderson MW. (1987).
Activation of the K-ras Protooncogene in Lung Tumors from Rats and Mice Chronically Exposed to Tetranitromethane. Cancer Res. 47:3212-3219.

Campen DB, Sloop TC, Maronpot RR, and Lucier GW. (1987). Continued Development of Hepatic g-Glutamyltranspeptidase – Positive Foci Upon Withdrawal of 17-a-Ethynylestradiol in
Diethylnitrosamine-initiated Rats. Cancer Res. 47:2328-2333.

Maronpot RR. (1987). Ovarian Toxicity and Carcinogenicity in Eight Recent National Toxicology Program Studies. EHP 73:124-130.

Melnick RL, Jameson CW, Goehl TJ, Maronpot RR, Collins BJ, Greenwell A, Harrington FW,
Wilson RE, Tomaszewski KE, and Agarwal DK. (1987). Application of Microencapsulation for
Toxicology Studies. II. Toxicity of Microencapsulated Trichloroethylene in Fischer 344 Rats. Fund. & App. Tox. 8:432-442.

Mitsumori K, Maronpot RR, and Boorman GA. (1987). Spontaneous Tumors of the Meninges in Rats. Vet. Path. 24:50-58.

Maronpot RR, Haseman JK, Boorman GA, Eustis SE, Rao GN, and Huff JE. (1987). Liver Lesions in B6C3F1 Mice: The National Toxicology Program, Experience and Position. Arch. Toxicol. Suppl. 10:10-26.

Miller BE, Chapin RE, Pinkerton KE, Gilmore LB, Maronpot RR, and Hook GER. (1987). Quantitation of Silica-Induced Type II Cell Hyperplasia by Using Alkaline Phosphatase Histochemistry in Glycol Methacrylate Embedded Lung. Exp. Lung Res. 12:135-148.
Ghanayem BI, Matthews HB, and Maronpot RR. (1987). Calcium Channel Blockers Protect Against Ethanol – and Indomethacin- Induced Gastric Lesions in Rats. Gastroenterology 92:106-111.

Dieter MP, Maronpot RR, and French JE. (1987). Biochemical Markers for Fischer Rat Leukemia in a Cell Transplant Model. Cancer Detection and Prevention 10:425-433.

Wilson WE, Hudson PM, Kanamatsu T, Walsh TJ, Tilson HA, Hong JS, Maronpot RR, and
Thompson M. (1986). Trimethyltin- Induced Alterations in Brain Amino Acids, Amines and Amine Metabolites: Relationship to Hyperammonemia. NeuroToxicology 7(3):63-74.

Yoshitomi K, Maronpot RR, Solleveld HA, and Boorman GA. (1986). Forestomach Ulcers in Crj:B6C3 (C57BL/6NCrj x C3H/HeNCrj) F1 Mice. Lab. Anim. Sci. 36(5):501-503.

Boorman GA, Hong HL, Jameson CW, Yoshitomi K, and Maronpot RR. (1986). Regression of Methyl Bromide Induced Forestomach Lesions in the Rat. Tox. & Appl. Pharmacol. 86:131-139.
Ghanayem BI, Maronpot RR, and Matthews HB, 1986. Ethyl Acrylate-Induced Gastric Toxicity. III. Development and Recovery of Lesions. Tox. & Appl. Pharmacol. 83:576-583.

Ghanayem BI, Maronpot RR, and Matthews HB. (1986). Association of Chemically Induced Forestomach Cell Proliferation and Carcinogenesis. Cancer Ltrs. 32:271-278.

Maronpot RR, Miller RA, Clarke WJ, Westerberg RB, Decker JR, and Moss OR. (1986). Toxicity of Formaldehyde Vapor in B6C3F1 Mice Exposed For 13 Weeks. Toxicology 41:253-266.

Maronpot RR, Shimkin MB, Smith LH, Witschi HP, and Cline JM. (1986). Strain A Mouse Pulmonary Tumor Test Results for Chemicals Previously Tested in the National Cancer Institute
Carcinogenicity Tests. JNCI. 76:1101-1112.

Maronpot RR, Montgomery CA, Boorman GA, and McConnell EE. (1986). National Toxicology
Program Nomenclature for Hepatoproliferative Lesions of Rats. Tox. Path. 14:163-273.

Klinger W, Devereux T, Maronpot RR, and Fouts J. (1986). Functional Hepatocellular Heterogeneity Determined by the Hepatotoxins Allyl Alcohol and Bromobenzene in Immature and Adult F344 Rats. Tox. & Appl. Pharmacol. 83:108-114.

Reynolds SH, Stowers SJ, Maronpot RR, Anderson MW, and Aaronson SA. (1986). Detection and Identification of Activated Oncogenes in Spontaneously Occurring Benign and Malignant Hepatocellular Tumors of the B6C3F1 Mouse. Proc. Nat’l. Acad. Sci. 83:33-37.

Garman RH, Snellings WM, and Maronpot RR. (1986). Frequency, Size and Location of Brain
Tumours in F-344 Rats Chronically Exposed to Ethylene Oxide. Fd. Chem. Tox. 24(2):145-153.

DePass LR, Woodside MD, Maronpot RR, and Weil CS. (1986). Three-Generation Reproduction and Dominant Lethal Mutagenesis Studies of Ethylene Glycol in the Rat. Fund. & Appl. Tox. 7:566- 572.
DePass LR, Garman RH, Woodside MD, Boyce JT, Giddens WE, Maronpot RR, and Weil CS, (1986). Chronic Toxicity and Oncogenicity Studies of Ethylene Glycol in Rats and Mice. Fund. &. Appl. Tox. 7:547-565.

DePass LR, Maronpot RR, and Weil WS. (1985). Dermal Oncogenicity Bioassays of Monofunctional and Multifunctional Acrylates and Acrylate-based Oligomers. J. Tox. and Environ. Hlth. 16:55-60.

Cline JM and Maronpot RR. (1985). Variations in the Histologic Distribution of Rat Bone Marrow Cells with Respect to Age and Anatomic Site. Tox. Path. 13:349-355.

Dieter MP, Maronpot RR, and French JF. (1985). Comparison of the Morphology and Enzyme Activity of Mononuclear Cells From Fischer 344 Rats with Either Spontaneous or Transplanted
Leukemia. Cancer Res. 45:4301-4307.

Lamb JC, Maronpot RR, Gulati DK, Russell VS, Hommel L, and Sabharwal PS. (1985). Reproductive and Developmental Toxicity of Ethylene Glycol in the Mouse. Tox. & Appl. Pharmacol. 81:100-112.

Garman RH, Snellings WM, and Maronpot RR. (1985) . Brain Tumors in F344 Rats Associated with Chronic Inhalation Exposure to Ethylene Oxide . NeuroToxicology 6:117-138.

Ghanayem BI, Maronpot RR, and Matthews HB. (1985). Ethyl Acrylate-Induced Gastric Toxicity. II.Structure – Toxicity Relationships and Mechanism. Tox. & Appl. Pharmacol. 80:336- 344.

Ghanayem BI, Maronpot RR, and Matthews HB. (1985). Ethyl Acrylate-Induced Gastric Toxicity. I. Effect of Single and Repetitive Dosing. Tox. & Appl. Pharmacol. 80:323-335.

Choy WN, MacGregor JT, Shelby MD, and Maronpot RR. (1985). Induction of Micronuclei by Benzene in B6C3F1 Mice: Retrospective Analysis of Peripheral Blood Smears from the NTP Carcinogenesis Bioassay. Mutation Res. 143:55-59.

Agarwal DK, Maronpot RR, Lamb IV JC, and Kluwe WM. (1985). Adverse Effects of Butyl Benzyl Phthalate on the Reproductive and Hematopoietic System of Male Rats. Toxicology 35:189-206.

Snellings WM, Weil CS, and Maronpot RR. (1984). A Subchronic Inhalation Study on the Toxicologic Potential of Ethylene Oxide in B6C3F1 Mice. Tox. & Appl. Pharmacol. 76:510-518.

Kluwe WM, Maronpot RR, Greenwell A, Harrington F. (1984). Interactions Between Bromobenzene Dose, Glutathione Concentrations, and Organ Toxicities in Single and Multiple Treatment Studies. Fund. & Appl. Tox. 4:1019-1028.

Snellings WM, Weil CS, and Maronpot RR. (1984). A Two-Year Inhalation Study of the Carcinogenic Potential of Ethylene Oxide in Fischer 344 Rats. Tox. & Appl. Pharmacol. 75:105-117.
Yang RSH, Garman RH, Maronpot RR, McKelvey JA, Weil CS, and Woodside MD. (1983). Acute and Subchronic Toxicity of Ethylenediamine in Laboratory Animals. Fund. & Appl. Tox. 3:512-520.

Maronpot RR, Zelenak JP, Weaver EV, and Smith NJ. (1983). Teratogenicity Study of Ethylene Glycol in Rats. Drug & Chem. Toxicol. 6:579-594.

Dodd DE, Snellings WM, Maronpot RR, and Ballantyne B. (1983). Ethylene Glycol Monobutyl Ether: Acute, 9-day, and 90-day Vapor Inhalation Studies in Fischer 344 Rats. Tox. & Appl. Pharmacol.68:405-414.

Maronpot RR, Witschi HP, Smith LH, and McCoy JL. (1983). Recent Experience with the Strain A Mouse Pulmonary Tumor Bioassay Model. In Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III. Environ. Sci. Res. 27:341-350.

Maronpot RR and Boorman GA. (1982). Interpretation of Rodent Hepatocellular Proliferative
Alterations and Hepatocellular Tumors in Chemical Safety Assessment. Tox. Path. 10:71-80.

Snellings WM, Maronpot RR, Zelenak JP, and Laffoon CP. (1982). Teratology Study in Fischer 344 Rats Exposed to Ethylene Oxide by Inhalation. Tox. & Appl. Pharmacol. 64:476-481.

Maronpot RR and Peterson LG. (1981). Spontaneous Proteus Nephritis Among Male C3H/HeJ Mice. Lab. Anim. Sci. 31:697-700.

Burton DS, Maronpot RR, and Howard FL. (1979). Frequency of Hydronephrosis in Wistar Rats. Lab. Anim. Sci. 29:642-644.

McGee MA and Maronpot RR. (1979). Harderian Gland Dacryoadenitis in Rats Resulting from Orbital Bleeding. Lab. Anim. Sci. 29:639-641.

Anderson LM, Budinger JM, Maronpot RR, and Good RA. (1978). Transplacental Lung Tumorigenesis in the Athymic Mouse. Cancer Res. 38:137-141.

Maronpot RR and Chavannes JM. (1977). Dacryoadenitis, Conjunctivitis, and Facial Dermatitis of the Mouse. Lab. Anim. Sci. 27:277.

Narisawa T, Wong CQ, Maronpot RR, and Weisburger JH. (1976). Large Bowel Carcinogenesis in Mice and Rats by Several Intrarectal doses of Methylnitrosourea and Negative Effect of Nitrite plus Methylurea. Cancer Res. 36:505-510.

Hecht SS, Loy M, Maronpot RR, and Hoffmann D. (1976). A Study of Chemical Carcinogenesis: Comparative Carcinogenicity of 5-Methylchrysene, Benzo (a) Pyrene and Modified Chrysenes. Cancer Ltrs. 1:147-153.

Hecht SS, Thorne RL, Maronpot RR, and Hoffman D. (1975). A Study of Tobacco Carcinogenesis. XIII. Tumor Promoting Subfractions of the Weakly Acidic Fraction. JNCI 55:1329-1336.
Hoffman D, Raineri R, Hecht S, Maronpot RR, and Wynder EL. (1975). A Study of Tobacco Carcinogenesis. XIV. Effects of N’-nitrosonornicotine and N’-nitrosoanabasine in Rats. JNCI
55:977-981.

Botros BAM and Maronpot RR. (1974). Complement-fixing and Indirect Fluorescent Antibodies in Sera of Dogs Experimentally Infected with Babesia Gibsoni. J. Egypt. Vet. Med. Assoc. 34:309-321.

Maronpot RR, Michael SA, and Botros BAM. (1974). Blood Parasites in Egyptian Domestic Animals. J. Egypt. Vet. Med. Assoc. 34:301-308.

Wilson BJ, Maronpot RR, and Hildebrandt PK. (1973). Equine Leukoencephalomalacia. J. Amer. Vet. Med. Assoc. 163:1293-1295.

Maronpot RR and Botros BAM. (1972). T oxoplasma Serologic Survey in Man and Domestic Animals in Egypt. J. Egypt. Pub. Hlth. Assoc. 47:58-67.

Maronpot RR and Barsoum IS. (1972). Leptospiral Microscopic Agglutinating Antibodies in Sera of Man and Domestic Animals in Egypt. Amer. J. Trop. Med. Hyg. 21:467-472.

Maronpot RR. (1972). Erythrocyte Glucose-6-Phosphate Dehydrogenase and Glutathione Deficiency in Sheep. Can. J. Comp. Med. 36:55-60.

Attia MAM, Williams RE, Maronpot RR, El Mour AF, and Moussa MI, 1971. Pathogenicity of Wad Medani Virus to Selected Animals. J. Egypt. Pub. Hlth. Assoc. 46:326-336.

Wilson BJ and Maronpot RR. (1971). Causative Fungus Agent of Leukoencephalomalacia in Equine Animals. Vet. Rec. 88:484-486.

Maronpot RR, Barsoum IS, and Ezzat E. (1971). Canine Leptospirosis in Cairo. United Arab Republic. The J. of Infectious Diseases. 123:548-550.

Waslien CI, Maronpot RR, and Kozman AR. (1970). Nutritional Studies in the Sand Rat (Psammomys obesus). Pahlavi Medical J. 1:228-233.

Michael SA, Maronpot RR, and Botros BAM. (1970). Blood Parasites in Egyptian Animals. Proc. 9th Arab Vet. Congress, Cairo, Egypt. pp. 236-254.

Botros BA M, Awad AY, Kozman AR, Hildebrandt PK, and Maronpot RR. (1970). Hematologic, Blood Electrolyte and Blood Biochemical Values of Egyptian Domesticated Animals. J. Egypt. Vet. Med. Assoc. 30:53-61.

Maronpot RR and Abd El Hei Refaii. (1970). The Histopathology of Klosiella Equi in Egyptian Equines. Proc. 9th Arab Vet. Congress, Cairo, Egypt. pp. 226-235.

Maronpot RR and Ezzat E. (1970). Hematologic Values for Cairo Dogs. Proc. 9th Arab Vet. Congress, Cairo, Egypt. pp. 124-134.
Maronpot RR and Guindy E. (1970). Preliminary Study of Babesia Gibsoni Patton in Wild Carnivores and Domesticated Dogs in Egypt. Amer. J. Vet. Res. 31:797-799.

Maronpot RR and Michael SA. (1968). Toxoplasmosis in Sheep. A Review. J. Egypt. Vet. Med. Assoc. 28:155-163.

Stedham MA, Bucci TJ, and Maronpot RR. (1968). Sexual and Asexual Phases of Aspergillus Nidulans in an Egret. Myopath. et Mycologia Appli. 36:289-292.

Maronpot RR, Stedman MA, and Bucci TJ. (1968). Focal Degenerative Myopathy in Turkeys. Avian Dis. 12:96-103.

Maronpot RR and Whitehair CK. (1967). Experimental Sprue-like Small Intestinal Lesions in Pigs. Can. J. Comp. Med. 31:309-316.

Books/Book Chapters:

Steinbach, TJ, Maronpot RR and Hardisty JF. 2015. Human Relevance of Rodent Leydig Cell Tumors. In: Hamilton & Hardy’s Industrial Toxicology, Sixth Edition, Harbison RD, Bourgeois, MM, and Johnson GT (Eds). John Wilye & Sons, New York. pp. 1191-1198.

Malarkey DE and Maronpot RR. (2005). Carcinogenesis. In: Encyclopedia of Toxicology. 2nd Edition. Wexler, P (Ed). Elsevier, New York. pp. 445-466.

Mastroides S and Maronpot RR. (2002). Carcinogenesis. In: Handbook of Toxicologic Pathology. 2nd Edition.Haschek WM, Russeaue CG and Wallig MA (Eds). Academic Press, San Diego. pp. 83-122.
Harada T, Enomoto A, Boorman GA and Maronpot RR. (1999). Liver and Gallbladder. . In: Pathology of the Mouse. Maronpot RR, Boorman GA and Gaul BW (Eds.). Cache River Press, Vienna, IL. pp. 119-184.

Nyska A and Maronpot RR. (1999). Adrenal Gland. In: Pathology of the Mouse. Maronpot RR,
Boorman GA and Gaul BW (Eds.). Cache River Press, Vienna, IL. pp. 509-536.

Maronpot, RR. (1998). Carcinogenesis. In: Encyclopedia of Toxicology. Wexler, P. (Ed.). Academic Press, New York. pp. 246-268.

Maronpot, RR. (1998) Chemical Carcinogenesis. In: Fundamentals of Toxicologic Pathology.Haschek, WM and Rousseaux, CG (Eds). Academic Press, New York. pp. 15-35.

Harada, T, Maronpot, RR, Enomoto, A, Tamano, S and Ward, JM. (1996). Changes in the liver and gallbladder. In: Pathobiology of the Aging Mouse. Volume 2. Mohr, U, Dungworth, DL, Capen, CC, Carlton, WW, Sundberg, JP and Ward, JM (Eds). ILSI Press, Washington, DC. pp: 207-241.

Devereux TR, Malarkey DE and Maronpot, RR. (1996). The Contribution of Rodent Liver and Lung Carcinogenesis Models to our Knowledge of the Cancer Latent Period. In Maltoni, C. (ed) , The Scientific Bases of Cancer Chemoprevention. Elsevier Publications, Amsterdam, Netherlands, pp. 45-59.

Kanno J, Ward JM, and Maronpot RR, (1996). Mechanisms of Chemically Induced Thyroid Follicular Carcinogenesis. In: Cellular and Molecular Mechanisms of Hormonal Carcinogenesis.
Environmental Influences. Huff J, Boyd J, and Barrett JC, eds. Wiley-Liss, NY, pp. 353-398.

Davis BJ and Maronpot RR. (1996). Chemically Associated Toxicity and Carcinogenicity of the
Ovary. In: Cellular and Molecular Mechanisms of Hormonal Carcinogenesis. Environmental
Influences. Huff J, Boyd J, and Barrett JC, eds. Wiley-Liss, NY, pp. 285-308.

Maronpot RR, Anna CH, Devereux TR, Lucier GW, Butterworth BE, and Anderson MW. (1995).
Considerations Concerning the Murine Hepatocarcinogenicity of Selected Chlorinated
Hydrocarbons. In: Implications for Risk Assessment. Wiley-Liss, Inc., NY, pp. 305-323.

Goodman DG, Maronpot RR, Newberne PN, Popp JA, and Squire RA. (1994). Proliferative and Selected Other Lesions in the Liver of Rats. In: Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, pp. 1-24.

Dixon D and Maronpot RR. (1994). Tumours of the Pancreas. In: Pathology of Tumours in
Laboratory Animals, Vol. 2. Tumours of the Mouse. IARC Publications, Lyon, pp. 281-303.

Johnson GA, Benveniste H, Black RR, Cofer GP, Gewalt SL, Hedlund LW, Maronpot RR, and
Suddarth SA. (1992). MR Microscopy of Disease Models. In: Magnetic Resonance Microscopy: Methods and Applications in Materials Science and Biomedicine. Blumich B and Kuhn W, eds. VHC, NY, pp. 501-511.

Anderson M, Stanley L, Devereux T, Reynolds S, and Maronpot R. (1992). Oncogenes in Mouse Liver Tumors. In: Comparative Molecular Carcinogenesis. Klein-Szanto AJP, Anderson MS, Barrett JC, and Slaga TJ, eds. Wiley-Liss, Inc., NY, pp. 187-201.

Clark G, Tritscher A, Maronpot R, Foley J, and Lucier G. (1991). Tumor Promotion by TCDD in
Female Rats. In: Banbury Report 35 – Biological Basis for Risk Assessment of Dioxins and Related Compounds. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp. 389-404.

Frantz JD, Betton G, Cartwright ME, Crissman JW, Macklin AW, and Maronpot RR. (1991).
Proliferative Lesions of the Non-glandular and Glandular Stomach in Rats. In: Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, pp. 1-20.

Ghanayem BI, Maronpot RR, and Matthews HB. (1991). Role of Chemically Induced Cell
Proliferation in Ethyl Acrylate-induced Forestomach Carcinogenesis. In: Chemically Induced Cell Proliferation: Implications for Risk Assessment. Butterworth BE, Slaga TJ, Farland W, and McClain M, eds. Vol. 369 of Progress in Clinical and Biological Research. Willy-Liss, Inc., NY, pp. 337-346.

Swenberg JA and Maronpot RR. (1991). Chemically Induced Cell Proliferation as a Criterion in
Selecting Doses for Long-term Bioassays. In: Chemically Induced Cell Proliferation: Implications for Risk Assessment . Butterworth BE, Slaga TJ, Farland W, and McClain M, eds. Vol. 369 of Progress in Clinical and Biological Research. Willy-Liss, Inc., NY, pp. 245-251.
Maronpot RR. (1991). Chemical Carcinogenesis. In: Handbook of Toxicologic Pathology. Haschek W and Rosseaux CG, eds. Academic Press, NY, pp. 99-129.

You M, Reynolds SH, Maronpot RR, Stoner GD, and Anderson MW. (1990). Activated Oncogenes in Rodent and Human Lung Tumors. In: Biology, Toxicology, and Carcinogenesis of Respiratory Epithelium. Thomassen DG and Nettesheim P, eds. Hemisphere Publishing Co., NY, pp. 271-287.

Belinsky SA, Walker VE, Uraih LC, Maronpot RR, Swenberg JA, and Anderson MW. (1990). Role of DNA Adduct Formation and Cell Proliferation in the Induction of Nasal Tumors in the Rat by the Tobacco Specific Carcinogen 4-(N-methyl-N-nitrosamino)-1- (3-pyridyl)-1-butanone. In: Nasal Carcinogenesis in Rodents: Relevance to Human Health Risk. Pudoc Wageningen, Netherlands, pp. 146-151.

Maronpot RR. (1990). Tumors of the Liver. In: Atlas of Tumor Pathology of the Fischer Rat. CRC Press, pp. 193-220.

Mitsumori K, Dittrich KL, Stefanski S, and Maronpot RR. (1988). Benign and Malignant Neoplasms, Meninges, Rat. In: ILSI Monograph on Pathology of Laboratory Animals – Nervous System. Springer-Verlag, NY, pp. 108-117.

Anderson MW, Maronpot RR, and Reynolds SH. (1988). Role of Oncogenes in Chemical
Carcinogenesis: Extrapolation from Rodents to Humans. In: Detection Methods for DNA-Damaging Agents in Men: Applications in Cancer Epidemiology and Prevention. Bartsch H, et al., eds. IARC Scientific Publication #89, Oxford Univ. Press, pp. 477-485.

Maronpot RR. (1986). Spontaneous Hydronephrosis in the Rat. In: ILSI Monograph on Pathology of Laboratory Animals – Urinary System. Springer-Verlag, NY, pp. 268-271.

Mennear J, Maronpot R, Boorman G, Eustis S, Huff J, Haseman J, McConnell E, Ragan H, and
Miller R. (1986). Toxicologic and Carcinogenic Effects of Inhaled Tetrachloroethylene in Rats and Mice. In: New Concepts and Developments in Toxicology. Chambers P L, Gehring P, and Sakai F, eds. pp. 201-210.

Maronpot RR. (1985). Considerations in the Evaluation and Interpretation of Long-Term Animal
Bioassays for Carcinogenicity. In: Handbook of Carcinogen Testing. Noyes Pub, NJ, pp. 372-382.

Other Major Reports/Activities:

Selected National & International Invited Presentations since 2007:

2015 Lectures
“Responsible Authorship & Publication Practices”, 31st Annual Meeting of the Japanese
Society of Toxicologic Pathology, Tokyo, Japan, January 28, 2015

“Non-neoplastic Rodent Liver Lesions”, BSTP Liver Module Course, Cambridge, UK ,
March 25, 2015

“Liver Carcinogenesis and Use of Rat and Mouse Models”, BSTP Liver Module Course,
Cambridge, UK, March 26, 2015

“Liver Lesions and Significance for Man”, BSTP Liver Module Course, Cambridge, UK,
March 27, 2015

2014 Lectures
“Practical Applications of MRI Histology in Toxicologic Pathology”, 30th Annual Meeting of the Japanese Society of Toxicologic Pathology, Tokushima, Japan, January 29, 2014

“Neoplastic and Non-neoplastic Rodent Thyroid Lesions and Their Relevance”, RTP Rodent Pathology Course, Research Triangle Park, NC, September 22, 2014

“Identifying Adverse Organ Responses: The Liver as Paradigm”, Annual Meeting of the American College of Toxicology, Orlando, Florida, November 11, 2014

2013 Lectures
“The Role of the Toxicologic Pathologist in the Post-Genomic Era” 29th Annual Meeting of the Japanese Society of Toxicologic Pathology, Tsukba, Tokyo, Japan, January 31, 2013.

“Responsible Authorship and Publication Practices”, AALAS Annual Meeting, Baltimore, MD, 28 October 2013

2012 Lectures

“Pathology of the Adrenal Gland” Daiichi-Sankyo, Tokyo, Japan, January 31, 2012.

“Rodent Pulmonary Lesions” JSTP Annual Meeting, Tokyo, Japan, February 1, 2012.
“Current and Past Rat Strains Used by the National Toxicology Program” Harlan Evening Seminar, Tokyo, Japan, February 3, 2012.

“Image Acquisition and Ethics” IATP Lecture at STP Annual Meeting, Boston, MA, June 27, 2012.

“Pathology of the Mouse: Past, Present and Future” ACVP Annual Meeting, Seattle, Oregon, December 4, 2012.

2011 Lectures
“Overview of Xenobiotic-Induced Hepatocellular Hypertrophy” 3rd International European
Society of Toxicologic Pathology Workshop, Ivrea, Italy. June 1, 2011.

“Rodent Lesions That Are Not Significant for Human Risk” Sumitomo Chemical Company
(January 25, 2011), DaiichiSankyo (January 31, 2011) and IET (February 1, 2011). Japan.

“Adverse Versus Adaptive Hepatic Enzyme Induction (Hypertrophy)” JSTP Annual Meeting, Osaka, Japan, January 27, 2011.

2010 Lectures
“Xenobiotic-induced Rodent Tumors of Questionable Relevance to Human Cancer Risk” 7th European Congress of Toxicologic Pathology, European Society of Toxicologic Pathology. The Hague, September 15-18, 2009.

“Xenobiotic-induced Toxicologic Pathology of the Liver.” The BSTP Gopinath Lecture.
7th European Congress of Toxicologic Pathology, European Society of Toxicologic Pathology. The Hague, September 15-18, 2009.

Contemporary Concepts in Target Organ Toxicologic Pathology: Hepatobiliary and Cardiovascular Systems “Background Lesions and Nomenclature” University of Illinois, Champaign/Urbana, Illinois. And “The Cancer Bioassay: Past, Present, and Future”, July 22, 2009.

Eighth Biennial Short Course: Toxicology & Pathology Drug Discovery and Development
University of Illinois, Champaign/Urbana, Illinois.
“The Cancer Bioassay: Past, Present, and Future”, July 21, 2009.

2009 Lectures
“Xenobiotic-induced Rodent Tumors of Questionable Relevance to Human Cancer Risk” 7th European Congress of Toxicologic Pathology, European Society of Toxicologic Pathology. The Hague, September 15-18, 2009.

“Xenobiotic-induced Toxicologic Pathology of the Liver.” The BSTP Gopinath Lecture.
7th European Congress of Toxicologic Pathology, European Society of Toxicologic Pathology. The Hague, September 15-18, 2009.

Contemporary Concepts in Target Organ Toxicologic Pathology: Hepatobiliary and Cardiovascular Systems “Background Lesions and Nomenclature” University of Illinois, Champaign/Urbana, Illinois.

“The Cancer Bioassay: Past, Present, and Future”, July 22, 2009.
Eighth Biennial Short Course: Toxicology & Pathology Drug Discovery and Development
University of Illinois, Champaign/Urbana, Illinois. And “The Cancer Bioassay: Past, Present, and Future”, July 21, 2009.

2008 Lectures
TEVA Pharmaceutical Company, Israel “The Cancer Bioassay: Past, Present, Future”
December 8, 2008

2nd East Mediterranean ICLAS Regional Meeting “Overview of Imaging Modalities and Control of Small Animal Physiology during Live Imaging” and “Application of MRI in Toxicology and Toxicologic Pathology”, Jerusalem, Israel, December 3-4, 2008

NTP Satellite Symposium, STP Annual meeting Conundrums in Toxicologic Pathology,
June 21, 2008, San Francisco

Aperio Research Triangle Park Digital Pathology Seminar, May 13, 2008, Lecture on “Digital Pathology for Peer Review and Phenotyping”

NIEHS February 2008 Lecture on “Comparative Medicine Branch Pathology/Case Presentations”

ILSI Annual Meeting, Rio Grande, Puerto Rico, January 2008. Organized symposium on “Applications of Small Animal Imaging in Toxicology Research and Testing”. Lectured on “Application of Magnetic Resonance Imaging in Toxicology and Toxicologic Pathology”.

2007 Lectures
National Academy of Science Workshop on Mouse Liver Tumors, Washington, DC, November 2007 “Mouse Models for Carcinogenicity”

American College of Veterinary Pathologists, Savannah, Georgia, November 2007, Lectured at a Continuing Education Course, Rodent Imaging Overview for the Pathologist “Magnetic Resonance Imaging”

American Association for Laboratory Animal Science Annual Meeting, Charlotte, NC, October 2007. The Wallace P. Rowe Lecture “The Cancer Bioassay: Challenges for the Future”
And Seminar on Current Imaging Modalities for Rodent Xenograft Models “MRI Imaging Systems”

7th Biennial Industrial Toxicology & Pathology Short Course, University of Illinois, July 2007
“Carcinogenicity Assessment” and “Application of Multimodality Imaging in Toxicologic Pathology”

Society of Toxicology Annual Meeting, Charlotte, NC, March 2007, Lectured at a Continuing Education Course, Rodent Imaging Overview for the Toxicologist, “Magnetic Resonance Imaging”

Editorial Review Board:

Senior Advisor – Toxicologic Pathology, 2005-Present
Editorial Board – Experimental & Toxicologic Pathology, 2001-Present
Editor – Toxicologic Pathology, 2001- 2004
Editorial Board – Toxicologic Pathology, 1986-2001
Section Editor, Laboratory Animal Pathology, 1996-2001
Editorial Board – Drug and Chemical Toxicology, 1986-1992
Editorial Board – Fundamental and Applied Toxicology, 1985-1991
Editorial Review Board – Environmental Health Perspectives, 1985-1992; 1994-1997
Editorial Board – Toxicology, 1988-1998

Editorial Activities:

Ad hoc Reviewer
American Journal of Pathology
American Journal of Respiratory Cell & Molecular Biology
Cancer
Cancer Research
Carcinogenesis
Comparative Medicine
Food and Chemical Toxicology
International Journal of Cancer
Molecular Carcinogenesis
Proceedings of the National Academy of Sciences (USA)
Toxicological Sciences

Co-Edited Symposia Proceedings:

Maronpot RR and Stitzel KA, 1989. Significance of Foci of Cellular Alteration in the Rat Liver. Tox. Path. 17, No. 4 (Part 1), 557-735.

Uraih LC, Morgan KT, and Maronpot RR, 1990. Symposium on Toxicologic Pathology of the Upper Respiratory System. EHP 85:161-352.

Alison R and Maronpot RR, 1987. Comparative Ovarian Pathology. EHP 73:3-130.

Edited Books:

Pathology of Genetically Engineered Mice. (2000). Ward, JM, Mahler, JF, Maronpot, RR, Sundberg, JP (Eds). Iowa State University Press, Ames, IA, pp. 394.

Maronpot RR. (1999). Pathology of the Mouse. Cache River Press, Vienna, VA, 699 pp.

Edited Monographs:

Guest Editor for A Monograph on Histomorphologic Evaluation of Lymphoid Organs
(2006). Toxicol Pathol 34 (5): 407-696.