The Legacy of the F344 Rat at the National Toxicology Program

The Legacy of the F344 Rat at the National Toxicology Program

This lecture is based on a 2016 publication in Critical Reviews in Toxicology (Vol 46:641-675) & also includes kidney and forestomach tumors in addition to mononuclear cell leukemia, Leydig cell tumors, and tunica vaginalis mesothelioma. 

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non-neoplastic-hepatobiliary-lecture

INHAND Non-Neoplastic Hepatobiliary Lesions

Material presented covers non-neoplastic rat and mouse lesions that are part of the INHAND nomenclature effort plus additional examples of liver tissue artifacts.

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Adverse, Non-adverse and Adaptive Responses in Toxicologic Pathology

Discussion of definitions of adversity followed by defining NOAELs using practical case examples of adverse, non-adverse and adaptive responses along with how to deal with lesion reversibility and exacerbation of background lesions in preclinical toxicology studies. Includes comments on justifying results to regulatory authorities.

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pathology-of-the-adrenal-gland-toxpath

Pathology of the Adrenal Gland

This toxicologic pathology presentation provided examples of normal, degenerative lesions of the rat and mouse adrenal gland and includes non-neoplastic proliferative lesions as well as common and rare adrenal cortical and medullary cancers.

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hepatotoxicity slide toxpath

Hepatotoxicity

A toxicologic pathology overview of liver toxicity including clinical and anatomic pathology, histopathology of toxic liver lesions, factors that influence liver toxicologic pathology, and case examples for establishing a NOAEL.

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Rat Liver Foci

A gallery of photomicrographs depicting the spectrum of foci of cellular alteration in the rat liver that might be encountered during toxicologic pathology evaluation of preclinical studies.

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Histopathology of Carcinogenesis

Histopathology of Carcinogenesis

This toxicologic pathology presentation covers basic principles and lexicon of carcinogenesis with representative photomicrographs and case presentations for evaluating potential cancer bioassay tumor responses.

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Rodent Liver Lesions – Neoplastic

This presentations is focused on microscopic features of rat and mouse neoplastic liver lesions that are commonly seen during toxicologic pathology evaluation of rat and mouse two-year cancer bioassays.

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Liver Carcinogenesis and Use of Rat and Mouse Models

Following a presentation of basic principles of carcinogenesis with emphasis on liver cancer development and intrinsic susceptibility factors, examples of specific rat and mouse animal models of hepatocarcinogenesis are provided.

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Xenobiotic-Induced Toxicologic Pathology of the Liver

Examples of chemical and drug-induced liver lesions including non-neoplastic and neoplastic proliferative changes typical found in prechronic and chronic rat and mouse toxicity studies are provided with photomicrograph examples.

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Rodent Tumors of Questionable Relevance to Man

Some species-specific rat and mouse tumor responses seen in cancer bioassays that are not relevant to human health risk include alpha-2u globulin induced renal cancer, urinary bladder tumors, carcinoids secondary to blockage of gastric acid secretion, various endocrine tumors, forestomach tumors, Zymbal’s gland tumors, preputial and clitoral gland tumors and Harderian gland tumors.

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Responsible Authorship and Publication Practices

Appropriate documentation of authorship and use of acknowledgements as well as how to put together a manuscript for scientific publication are presented. In addition examples of the ethics of image and figures adjustment for inclusion in submitted manuscripts are provided.

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