Toxicologic Pathology Articles

Continuous exposure to amorphous formula of curcumin from the developmental stage facilitates anti-anxiety-like behavior and fear-extinction learning in rats

2021-05-29T18:44:44+00:00

An amorphous formula of curcumin (CUR) has shown to enable an improved bioavailability after ingestion. The aim of this study was to investigate the hypothesis that exogenously administered CUR has an advantage in ameliorating post-traumatic stress disorder at low doses. To this end, Long-Evans rats were dietary exposed to CUR at 0.1% or [...]

Continuous exposure to amorphous formula of curcumin from the developmental stage facilitates anti-anxiety-like behavior and fear-extinction learning in rats2021-05-29T18:44:44+00:00

Embryo-fetal developmental toxicity study of alpha-glycosyl isoquercitrin administered orally to New Zealand White rabbits

2020-10-22T16:43:38+00:00

An embryo-fetal survival and development study was conducted to augment the toxicity database for alpha-glycosyl isoquercitrin (AGIQ), a generally recognized as safe (GRAS) additive and flavor in food and beverages. In Phase I, 24 naturally mated New Zealand white (NZW) female rabbits per group were administered AGIQ by oral gavage at 0, 250, [...]

Embryo-fetal developmental toxicity study of alpha-glycosyl isoquercitrin administered orally to New Zealand White rabbits2020-10-22T16:43:38+00:00

Continuous exposure to α-glycosyl isoquercitrin from developmental stages to adulthood is necessary for facilitating fear extinction learning in rats

2021-05-19T19:07:47+00:00

We previously reported that exposure to α-glycosyl isoquercitrin (AGIQ) from the fetal stage to adulthood facilitated fear extinction learning in rats. The present study investigated the specific AGIQ exposure period sufficient for inducing this behavioral effect. Rats were dietarily exposed to 0.5% AGIQ from the postweaning stage to adulthood (PW-AGIQ), the fetal stage [...]

Continuous exposure to α-glycosyl isoquercitrin from developmental stages to adulthood is necessary for facilitating fear extinction learning in rats2021-05-19T19:07:47+00:00

Synthetic and Natural Food Colorants

2020-05-21T17:28:39+00:00

There is increasing contemporary appeal and interest in natural versus synthetic food and beverage colorants based on increasing health awareness and global demand for chemical-free food products. There are many commonalities in defining and regulating food colorants among countries and specifics are provided for the United States, the European Union, and Japan. Overall [...]

Synthetic and Natural Food Colorants2020-05-21T17:28:39+00:00

Safety Assessment Testing Requirements for Food Color Additives

2020-05-21T17:25:50+00:00

Safety assessment of food colorants are fundamentally similar in Japan, Europe, and the United States and involve large amounts of data for new colorants and active monitoring of existing approved colorants. Testing requirement are similar for artificial and natural food colorants and include assays for genetic damage and use of animal toxicity studies [...]

Safety Assessment Testing Requirements for Food Color Additives2020-05-21T17:25:50+00:00

The Pathology of Selected Dietary Herbal Medicines as Observed in the National Toxicology Program Studies

2020-05-21T17:11:28+00:00

The popularity of herbal medicines is growing steadily all over the world, and a large number of people are using these products for self-medication. Although these medicines are being widely used, and the number of available products is increasing exponentially, most of these compounds have not been properly evaluated for potential toxic or [...]

The Pathology of Selected Dietary Herbal Medicines as Observed in the National Toxicology Program Studies2020-05-21T17:11:28+00:00

Food Color Additives

2020-05-21T17:03:45+00:00

This issue of the Foods and Food Ingredients of Japan includes a special section of papers that focus on synthetic and natural food additive colorants with presentation of governmental regulatory procedures in the U.S., Europe and Japan in bringing food colorants to the marketplace. While the food colorant marketplace is still dominated by [...]

Food Color Additives2020-05-21T17:03:45+00:00

Identification of compound causing yellow bone discoloration following alpha-glycosyl isoquercitrin exposure in Sprague–Dawley rats

2021-05-11T17:15:04+00:00

Previous rat toxicity studies of alpha-glycosyl isoquercitrin (AGIQ), a water-soluble flavonol glycoside derived from rutin, revealed systemic yellow bone discoloration. This investigative study was conducted to determine the AGIQ metabolite(s) responsible for the discoloration. Female Sprague–Dawley rats were administered dietary AGIQ at doses of 0%, 1.5%, 3.0%, or 5.0% (0, 1735.0, 3480.8, and [...]

Identification of compound causing yellow bone discoloration following alpha-glycosyl isoquercitrin exposure in Sprague–Dawley rats2021-05-11T17:15:04+00:00

Contemporary activities of Toxicologic Pathology Societies

2020-04-26T17:39:18+00:00

Educational activities and training opportunities in toxicologic pathology are major goals of 9 formally established Toxicologic Pathology Societies and the International Academy of Toxicologic Pathology. Some Toxicologic Pathology Societies have examination-based certification programs while others accept certification or registration by veterinary pathology organizations including the American College of Veterinary Pathologists, the European College [...]

Contemporary activities of Toxicologic Pathology Societies2020-04-26T17:39:18+00:00

Contemporary Activities of Toxicologic Pathology Societies (SAGE)

2020-04-29T15:48:29+00:00

Abstract: Educational activities and training opportunities in toxicologic pathology are major goals of 9 formally established Toxicologic Pathology Societies and the International Academy of Toxicologic Pathology. Some Toxicologic Pathology Societies have examination-based certification programs while others accept certification or registration by veterinary pathology organizations including the American College of Veterinary Pathologists, the European [...]

Contemporary Activities of Toxicologic Pathology Societies (SAGE)2020-04-29T15:48:29+00:00