Defining Adverse, Non-adverse and Adaptive Responses in Safety/Risk Assessment

The judgment on the adverse nature of an observation in a non-clinical toxicology study is subject to discussion, challenge, and reinterpretation.

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Carcinogenesis – World Toxicologic Pathology Congress

This carcinogenesis lecture created as part of a day course dealing with pathology for non-pathologists. Basic concepts are presented with pathology examples

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The Legacy of the F344 Rat at the National Toxicology Program

The Legacy of the F344 Rat at the National Toxicology Program

This lecture is based on a 2016 publication in Critical Reviews in Toxicology (Vol 46:641-675) & also includes kidney and forestomach tumors in addition to mononuclear cell leukemia, Leydig cell tumors, and tunica vaginalis mesothelioma. 

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non-neoplastic-hepatobiliary-lecture

INHAND Non-Neoplastic Hepatobiliary Lesions

Material presented covers non-neoplastic rat and mouse lesions that are part of the INHAND nomenclature effort plus additional examples of liver tissue artifacts.

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Adverse, Non-adverse and Adaptive Responses in Toxicologic Pathology

Discussion of definitions of adversity followed by defining NOAELs using practical case examples of adverse, non-adverse and adaptive responses along with how to deal with le