The Legacy of the F344 Rat at the National Toxicology Program
This lecture is based on a 2016 publication in Critical Reviews in Toxicology (Vol 46:641-675) & also includes kidney and forestomach tumors in addition to mononuclear cell leukemia, Leydig cell tumors, and tunica vaginalis mesothelioma.
Adverse, Non-adverse and Adaptive Responses in Toxicologic Pathology
Discussion of definitions of adversity followed by defining NOAELs using practical case examples of adverse, non-adverse and adaptive responses along with how to deal with lesion reversibility and exacerbation of background lesions in preclinical toxicology studies. Includes comments on justifying results to regulatory authorities.
This toxicologic pathology presentation provided examples of normal, degenerative lesions of the rat and mouse adrenal gland and includes non-neoplastic proliferative lesions as well as common and rare adrenal cortical and medullary cancers.
A toxicologic pathology overview of liver toxicity including clinical and anatomic pathology, histopathology of toxic liver lesions, factors that influence liver toxicologic pathology, and case examples for establishing a NOAEL.