
Defining Adverse, Non-adverse and Adaptive Responses in Safety/Risk Assessment
The judgment on the adverse nature of an observation in a non-clinical toxicology study is subject to discussion, challenge, and reinterpretation.

Carcinogenesis – World Toxicologic Pathology Congress
This carcinogenesis lecture created as part of a day course dealing with pathology for non-pathologists. Basic concepts are presented with pathology examples

The Legacy of the F344 Rat at the National Toxicology Program
This lecture is based on a 2016 publication in Critical Reviews in Toxicology (Vol 46:641-675) & also includes kidney and forestomach tumors in addition to mononuclear cell leukemia, Leydig cell tumors, and tunica vaginalis mesothelioma.

INHAND Non-Neoplastic Hepatobiliary Lesions
Material presented covers non-neoplastic rat and mouse lesions that are part of the INHAND nomenclature effort plus additional examples of liver tissue artifacts.

Adverse, Non-adverse and Adaptive Responses in Toxicologic Pathology
Discussion of definitions of adversity followed by defining NOAELs using practical case examples of adverse, non-adverse and adaptive responses along with how to deal with lesion reversibility and exacerbation of background lesions in preclinical toxicology studies. Includes comments on justifying results to regulatory authorities.

Pathology of the Adrenal Gland
This toxicologic pathology presentation provided examples of normal, degenerative lesions of the rat and mouse adrenal gland and includes non-neoplastic proliferative lesions as well as common and rare adrenal cortical and medullary cancers.

Hepatotoxicity
A toxicologic pathology overview of liver toxicity including clinical and anatomic pathology, histopathology of toxic liver lesions, factors that influence liver toxicologic pathology, and case examples for establishing a NOAEL.