Toxicologic Pathology Articles and Publications

/Toxicologic Pathology Articles and Publications
Toxicologic Pathology Articles and Publications 2017-12-14T20:35:21+00:00

Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential

Quercetin and its glycosides possess potential benefits to human health. Several flavonols are available to consumers as dietary supplements, promoted as anti-oxidants; however, incorporation of natural quercetin glycosides into food and beverage products has been limited by poor miscibility [...]

New Technologies: Real-time Telepathology Systems – Novel Cost-effective Tools for Real-time Consultation and Data Sharing

Abstract: Real-time telepathology for use in investigative and regulated preclinical toxicology studies is now feasible. Newly developed microscope-integrated telepathology systems enable geographically remote stakeholders to view the live histopathology slide as seen by [...]

Imaging Applications in Toxicologic Pathology – Recommendations for Use in Regulated Non-Clinical Toxicity Studies

Available imaging systems for use in preclinical toxicology studies increasingly show utility as important tools in the toxicologic pathologist’s armamentarium, permit longitudinal evaluation of functional and morphological changes in tissues, and provide important [...]

Compact Magnetic Resonance Imaging Systems – Novel Cost-Effective Tools for Preclinical Drug Safety and Efficacy Evaluation

Practical magnetic resonance imaging for use in investigative and preclinical toxicology studies is now feasible. Newly developed, self-containing imaging systems provide an efficient and cost-effective means to rapidly obtain in vivo and ex vivo [...]

Ninety-day toxicity and single-dose toxicokinetics study of alpha-glycosyl isoquercitrin in Sprague-Dawley rat

alpha-Glycosyl isoquercitrin (AGIQ) is highly absorbable and has been shown to possess antioxidative properties. Based on a favorable safety profile, it has been confirmed as generally recognized as safe (GRAS) compound by the [...]

The Legacy of the F344 Rat as a Cancer Bioassay Model (A Retrospective Summary of Three Common F344 Neoplasms)

Robert R. Maronpot1, Abraham Nyska2, Jennifer E. Foreman3, Yuval Ramot4 1Maronpot Consulting LLC, Raleigh, North Carolina, USA, 2Sackler School of Medicine, Tel Aviv University and Timrat, Israel, 3ExxonMobil Biomedical Sciences, Inc., Annadale, New Jersey, [...]

Safety Assessment and Single-dose Toxicokinetics of the Flavouring Agent Myricitrin in Sprague–Dawley Rats

Myricitrin, a flavonol rhamnoside of myricetin extracted from the Chinese bayberry (Myrica rubra Siebold) plant, has been used in Japan since 1992 as a flavour modifier in snack foods, dairy products, and beverages. [...]