Yearly Archives: 2005

/2005

New Insights into Functional Aspects of Liver Morphology

2017-01-11T22:13:53+00:00

The liver is structurally and functionally complex and has been considered second only to brain in its complexity. Many mysteries still exist in this heterogeneous tissue whose functional unit of the lobule has continued to stump morphologists for over 300 years. The primary lobule, proposed by Matsumoto in 1979, has been gaining acceptance [...]

New Insights into Functional Aspects of Liver Morphology 2017-01-11T22:13:53+00:00

Carcinogenesis

2017-01-11T22:13:53+00:00

Cancer, or neoplasia, which occurs in one of every four individuals and results in the death of one of every five individuals in the United States, is a complex disease with multiple causes. Many intrinsic and extrinsic factors influence the development of cancer. Intrinsic or host factors include age, sex, genetic [...]

Carcinogenesis 2017-01-11T22:13:53+00:00

An Investigation of the Effects of Late-Onset Dietary Restriction on Prostate Cancer Development in the TRAMP Mouse

2017-01-11T22:13:53+00:00

In our previous work we showed that dietary restriction initiated at puberty reduced prostate cancer development in the TRAMP mouse model. The current study was conducted to ascertain whether a dietary restriction regime would similarly reduce lesion development if imposed once tumor development was well established. Male TRAMP mice were maintained on an [...]

An Investigation of the Effects of Late-Onset Dietary Restriction on Prostate Cancer Development in the TRAMP Mouse 2017-01-11T22:13:53+00:00

Microarray Data Analysis of Mouse Neoplasia

2017-01-11T22:13:54+00:00

Microarray gene expression analysis offers great promise to help us understand the molecular events of experimental carcinogenesis, but have such promises been fulfilled? Studies of gene expression profiles of rodent are being published and demonstrate that yes, indeed, gene array data is furthering our understanding of tumor biology. Recent studies have identified differentially [...]

Microarray Data Analysis of Mouse Neoplasia 2017-01-11T22:13:54+00:00