Yearly Archives: 2013

/2013

The Role of the Toxicologic Pathologist in the Post-Genomic Era

2017-01-11T22:13:22+00:00

An era can be defined as a period in time identified by distinctive character, events, or practices. We are now in the genomic era. The pre-genomic era: There was a pre-genomic era. It started many years ago with novel and seminal animal experiments, primarily directed at studying cancer. It is marked by the [...]

The Role of the Toxicologic Pathologist in the Post-Genomic Era 2017-01-11T22:13:22+00:00

In Vivo Noninvasive Detection of Brown Adipose Tissue through Intermolecular Zero-Quantum MRI

2017-01-11T22:13:22+00:00

Rosa T. Branca , Le Zhang, Warren S. Warren, Edward Auerbach, Arjun Khanna, Simone Degan, Kamil Ugurbil, Robert Maronpot The recent discovery of active Brown Adipose Tissue (BAT) in adult humans has opened new avenues for obesity research and treatment, as reduced BAT activity seem to be implicated in human energy imbalance, diabetes, [...]

In Vivo Noninvasive Detection of Brown Adipose Tissue through Intermolecular Zero-Quantum MRI 2017-01-11T22:13:22+00:00

Carcinogenesis: Mechanisms and Manifestations

2017-01-11T22:13:22+00:00

We foresee cancer research as an increasingly logical science, in which complexities are manifestations of a small set of underlying organizing principles. (Hanahan and Weinberg, 2011) 1. INTRODUCTION 1.1. Overview Cancer is a major cause of debilitation and death in humans and animals. Cancer develops as a function of age, environment, diet, and genetic [...]

Carcinogenesis: Mechanisms and Manifestations 2017-01-11T22:13:22+00:00

Proceedings of the 2013 Joint JSTP/NTP Satellite Symposium

2017-01-11T22:13:22+00:00

The first joint Japanese Society of Toxicologic Pathology (JSTP) and National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri,” was held on January 29th at Okura Frontier Hotel in Tsukuba, Ibaraki, Japan, in advance of the JSTP’s 29th Annual Meeting. The goal of this Symposium was to present current diagnostic pathology or nomenclature [...]

Proceedings of the 2013 Joint JSTP/NTP Satellite Symposium 2017-01-11T22:13:22+00:00

Immunohistochemistry on decalcified rat nasal cavity: trials and successes

2017-01-11T22:13:22+00:00

Immunohistochemical (IHC) staining for Casein Kinase 2 alpha (CK2a), cyclin-dependent kinase inhibitor 1B (p27Kip1), and heat shock protein 90 (HSP90) was performed on four levels of decalcified rat nasal cavity from four male and three female controls following nose-only exposure to ambient air for 5 days. Successful staining with negligible background artifact was [...]

Immunohistochemistry on decalcified rat nasal cavity: trials and successes 2017-01-11T22:13:22+00:00

Evaluation Of 90-day Oral Rat Toxicity Studies On The Food Additive, Gum Ghatti

2017-01-11T22:13:22+00:00

Gum ghatti, a polysaccharide of natural origin, is used in foods as a thickening, gelling, emulsifying and stabilizing agent. In a 90-day toxicity study following Organization for Economic Co-operation and Development (OECD) Guideline #408, male and female Sprague–Dawley rats were exposed to 0 (control), 0.5, 1.5 and 5% gum ghatti in AIN-93M basal [...]

Evaluation Of 90-day Oral Rat Toxicity Studies On The Food Additive, Gum Ghatti 2017-01-11T22:13:22+00:00