Yearly Archives: 2016

/2016

Recommendations from the INHAND Apoptosis/Necrosis Working Group

2017-01-11T22:14:41+00:00

Historically, there has been confusion relating to the diagnostic nomenclature for individual cell death. Toxicologic pathologists have generally used the terms “single cell necrosis” and “apoptosis” interchangeably. Increased research on the mechanisms of cell death in recent years has led to the understanding that apoptosis and necrosis involve different cellular pathways and that [...]

Recommendations from the INHAND Apoptosis/Necrosis Working Group 2017-01-11T22:14:41+00:00

Ninety-day toxicity and single-dose toxicokinetics study of alpha-glycosyl isoquercitrin in Sprague-Dawley rat

2017-01-11T22:14:41+00:00

alpha-Glycosyl isoquercitrin (AGIQ) is highly absorbable and has been shown to possess antioxidative properties. Based on a favorable safety profile, it has been confirmed as generally recognized as safe (GRAS) compound by the FDA. Nevertheless, safety and toxicity information for AGIQ is still sparse. Therefore, the aim of this study was to test [...]

Ninety-day toxicity and single-dose toxicokinetics study of alpha-glycosyl isoquercitrin in Sprague-Dawley rat 2017-01-11T22:14:41+00:00

Genotoxicity Assessment of the Flavouring Agent, Perillaldehyde

2017-01-11T22:14:41+00:00

Perillaldehyde, a natural monocyclic terpenoid found most abundantly in the herb perilla, has a long history of use as a flavouring ingredient to add spiciness and citrus taste to foods. Previously, it was judged to be safe by several international expert panels. To confirm the safety of flavourings placed on the European Union [...]

Genotoxicity Assessment of the Flavouring Agent, Perillaldehyde 2017-01-11T22:14:41+00:00

The Legacy of the F344 Rat as a Cancer Bioassay Model (A Retrospective Summary of Three Common F344 Neoplasms)

2017-01-11T22:13:21+00:00

Robert R. Maronpot1, Abraham Nyska2, Jennifer E. Foreman3, Yuval Ramot4 1Maronpot Consulting LLC, Raleigh, North Carolina, USA, 2Sackler School of Medicine, Tel Aviv University and Timrat, Israel, 3ExxonMobil Biomedical Sciences, Inc., Annadale, New Jersey, USA,  4Hadassah-Hebrew University Medical Center, Jerusalem, Israel Keywords: Mononuclear cell leukemia, LGL leukemia, Leydig cell tumor, tunica vaginalis mesothelioma, cancer [...]

The Legacy of the F344 Rat as a Cancer Bioassay Model (A Retrospective Summary of Three Common F344 Neoplasms) 2017-01-11T22:13:21+00:00

Genetic and Rat Toxicity Studies of Cyclodextrin Glucanotransferase

2017-01-11T22:13:22+00:00

Highlights • Bacterial cyclodextrin glucanotransferase (CGTase) is used to produce a water soluble form of glycosylated isoquercitrin. • Genotoxicity battery on CGTase and sodium sulfate negative for mutations and DNA damage. • No evidence of systemic toxicity in 90-day rat toxicity study of CGTase Introduction Microbiologically derived cyclodextrin glucanotransferase (CGTase) is used commercially as a processing [...]

Genetic and Rat Toxicity Studies of Cyclodextrin Glucanotransferase 2017-01-11T22:13:22+00:00

Recommendations from the INHAND Apoptosis/Necrosis Working Group

2017-01-11T22:13:22+00:00

Historically, there has been confusion relating to the diagnostic nomenclature for individual cell death. Toxicologic pathologists have generally used the terms ‘‘single cell necrosis’’ and ‘‘apoptosis’’ interchangeably. Increased research on the mechanisms of cell death in recent years has led to the understanding that apoptosis and necrosis involve different cellular pathways and that [...]

Recommendations from the INHAND Apoptosis/Necrosis Working Group 2017-01-11T22:13:22+00:00