Relevance of Animal Carcinogenesis Findings to Human Cancer Predictions and Prevention
Use of laboratory animals to identify carcinogenic potential of chemicals, mixtures, and other agents has a modern history of greater than 40 years from which much useful scientific and public health information can [...]
DNA Damage in Nasal and Brain Tissues of Canines Exposed to Air Pollutants Is Associated with Evidence of Chronic Brain Inflammation and Neurodegeneration
Acute, subchronic, or chronic exposures to particulate matter (PM) and pollutant gases affect people in urban areas and those exposed to fires, disasters, and wars. Respiratory tract inflammation, production of mediators of inflammation [...]
A Retrospective Analysis of Background Lesions and Tissue Accountability for Male Accessory Sex Organs in Fischer-344 Rats
Because the paired lobes (ventral, dorsal, lateral, and anterior) of the rat prostate have not been consistently sampled in many carcinogenicity and toxicity studies, comparison among different investigations has been compromised. The lack [...]
Measurement of Cell Replication and Apoptosis in Mice
Maronpot et al., 2000. Chapter 5 in Pathology of Genetically Engineered Mice. Iowa State University Press. This chapter focuses primarily on practical methods for assessing cell proliferation and apoptosis in tissue sections from mice, including [...]