Robert Maronpot

/Robert Maronpot

About Robert Maronpot

Dr. Maronpot received his doctorate of veterinary medicine in 1965 from Michigan State University, an MS in nutritional pathology from Michigan State University in 1966, and an MPH from Harvard University in 1972. He is a diplomate of the American College of Veterinary Pathologists as well as the American Board of Toxicology and has worked more than forty years in experimental pathology, with an emphasis on animal models of carcinogenesis.

Proceedings of the 2009 National Toxicology Program Satellite Symposium

2017-01-11T22:13:35+00:00

The National Toxicology Program (NTP) Satellite Symposium is a one-day meeting that is held in conjunction with the annual Society of Toxicologic Pathology (STP) meeting. The topic of the 2009 Symposium was ‘‘Tumor Pathology and INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Nomenclature.’’ The goal of [...]

Proceedings of the 2009 National Toxicology Program Satellite Symposium 2017-01-11T22:13:35+00:00

Furan-induced dose-response relationships for liver cytotoxicity, cell proliferation, and tumorigenicity (furan-induced liver tumorigenicity)

2017-01-11T22:13:35+00:00

Rodent studies of furan are associated with liver cell necrosis, release of liver-associated enzymes, increased hepatocyte proliferation, and hepatocarcinogenesis. For carcinogens whose proposed mode of action is cytolethality, it is hypothesized that the dose-response curve for tumor development would parallel the dose-response curve for cell death with compensatory proliferation in the target organ. To prospectively [...]

Furan-induced dose-response relationships for liver cytotoxicity, cell proliferation, and tumorigenicity (furan-induced liver tumorigenicity) 2017-01-11T22:13:35+00:00

Biological Basis of Differential Susceptibility to Hepatocarcinogenesis among Mouse Strains

2017-01-11T22:13:35+00:00

There is a vast amount of literature related to mouse liver tumorigenesis generated over the past 60 years, not all of which has been captured here. The studies reported in this literature have generally been state of the art at the time they were carried out. A PubMed search on the topic “mouse [...]

Biological Basis of Differential Susceptibility to Hepatocarcinogenesis among Mouse Strains 2017-01-11T22:13:35+00:00

Immunotoxicity and Environment: Immunodysregulation and Systemic Inflammation in Children

2017-01-11T22:13:35+00:00

Environmental pollutants, chemicals, and drugs have an impact on children’s immune system development. Mexico City (MC) children exposed to significant concentrations of air pollutants exhibit chronic respiratory inflammation, systemic inflammation, neuroinflammation, and cognitive deficits. We tested the hypothesis that exposure to severe air pollution plays a role in the immune responses of asymptomatic, [...]

Immunotoxicity and Environment: Immunodysregulation and Systemic Inflammation in Children 2017-01-11T22:13:35+00:00

Summary of Chemically Induced Pulmonary Lesions in the National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies

2017-01-11T22:13:35+00:00

The lung is the second most common target site of neoplasia of chemicals tested by the National Toxicology Program (NTP). Of all peer-reviewed NTP studies to date (N = 545), a total of sixty-four chemicals in sixty-six reports produced significant site-specific neoplasia in the lungs of rats and/or mice. Of the studies associated [...]

Summary of Chemically Induced Pulmonary Lesions in the National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies 2017-01-11T22:13:35+00:00

New Insights into Functional Aspects of Liver Morphology

2017-01-11T22:13:53+00:00

The liver is structurally and functionally complex and has been considered second only to brain in its complexity. Many mysteries still exist in this heterogeneous tissue whose functional unit of the lobule has continued to stump morphologists for over 300 years. The primary lobule, proposed by Matsumoto in 1979, has been gaining acceptance [...]

New Insights into Functional Aspects of Liver Morphology 2017-01-11T22:13:53+00:00

Carcinogenesis

2017-01-11T22:13:53+00:00

Cancer, or neoplasia, which occurs in one of every four individuals and results in the death of one of every five individuals in the United States, is a complex disease with multiple causes. Many intrinsic and extrinsic factors influence the development of cancer. Intrinsic or host factors include age, sex, genetic [...]

Carcinogenesis 2017-01-11T22:13:53+00:00

An Investigation of the Effects of Late-Onset Dietary Restriction on Prostate Cancer Development in the TRAMP Mouse

2017-01-11T22:13:53+00:00

In our previous work we showed that dietary restriction initiated at puberty reduced prostate cancer development in the TRAMP mouse model. The current study was conducted to ascertain whether a dietary restriction regime would similarly reduce lesion development if imposed once tumor development was well established. Male TRAMP mice were maintained on an [...]

An Investigation of the Effects of Late-Onset Dietary Restriction on Prostate Cancer Development in the TRAMP Mouse 2017-01-11T22:13:53+00:00

Microarray Data Analysis of Mouse Neoplasia

2017-01-11T22:13:54+00:00

Microarray gene expression analysis offers great promise to help us understand the molecular events of experimental carcinogenesis, but have such promises been fulfilled? Studies of gene expression profiles of rodent are being published and demonstrate that yes, indeed, gene array data is furthering our understanding of tumor biology. Recent studies have identified differentially [...]

Microarray Data Analysis of Mouse Neoplasia 2017-01-11T22:13:54+00:00

Brain Inflammation and Alzheimer’s-Like Pathology in Individuals Exposed to Severe Air Pollution

2017-01-11T22:13:54+00:00

Air pollution is a complex mixture of gases (e.g., ozone), particulate matter, and organic compounds present in outdoor and indoor air. Dogs exposed to severe air pollution exhibit chronic inflammation and acceleration of Alzheimer’s-like pathology, suggesting that the brain is adversely affected by pollutants. We investigated whether residency in cities with high levels [...]

Brain Inflammation and Alzheimer’s-Like Pathology in Individuals Exposed to Severe Air Pollution 2017-01-11T22:13:54+00:00