Robert Maronpot

/Robert Maronpot

About Robert Maronpot

Dr. Maronpot received his doctorate of veterinary medicine in 1965 from Michigan State University, an MS in nutritional pathology from Michigan State University in 1966, and an MPH from Harvard University in 1972. He is a diplomate of the American College of Veterinary Pathologists as well as the American Board of Toxicology and has worked more than forty years in experimental pathology, with an emphasis on animal models of carcinogenesis.

Responsible Authorship and Publication Practices

2017-01-11T22:13:35+00:00

Robert R. Maronpot A panel and audience discussion co-sponsored by the International Academy of Toxicologic Pathology (IATP) and the Society of Toxicologic Pathology (STP) at the STP Annual Meeting in Denver in June 2011 generated some lively dialogue. The theme of the ninety-minute session was ‘‘Responsible Authorship and Publication Practices.’’ Following some general [...]

Responsible Authorship and Publication Practices 2017-01-11T22:13:35+00:00

Proceedings of the 2010 National Toxicology Program Satellite Symposium

2017-01-11T22:13:35+00:00

The 2010 annual National Toxicology Program (NTP) Satellite Symposium, entitled ‘‘Pathology Potpourri,’’ was held in Chicago, Illinois, in advance of the scientific symposium sponsored jointly by the Society of Toxicologic Pathology (STP) and the International Federation of Societies of Toxicologic Pathologists (IFSTP). The goal of the annual NTP Symposium is to present current [...]

Proceedings of the 2010 National Toxicology Program Satellite Symposium 2017-01-11T22:13:35+00:00

Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

2017-01-11T22:13:35+00:00

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose [...]

Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System 2017-01-11T22:13:35+00:00

Liver Enlargement – Hepatic Enzyme Induction: Histopathology

2017-01-11T22:13:35+00:00

Hepatic enzyme induction is generally an adaptive response associated with increases in liver weight, induction of gene expression, and morphological changes in hepatocytes. The additive growth and functional demands that initiated the response to hepatic enzyme induction cover a wide range of stimuli including pregnancy and lactation, hormonal fluctuations, dietary constituents, infections associated [...]

Liver Enlargement – Hepatic Enzyme Induction: Histopathology 2017-01-11T22:13:35+00:00

Introduction to Hepatic Drug Metabolizing Enzyme Induction in Drug Safety Evaluation Studies

2017-01-11T22:13:35+00:00

The following three articles represent the output of a combined effort initiated by the Scientific Regulatory Policy Committee of the Society of Toxicologic Pathology to provide a unified review of current scientific practices and relevant literature and provide suggestions regarding the recognition, interpretation, and risk assessment of hepatic drug metabolizing enzyme (DME) induction [...]

Introduction to Hepatic Drug Metabolizing Enzyme Induction in Drug Safety Evaluation Studies 2017-01-11T22:13:35+00:00

Pathology Peer Review

2017-01-11T22:13:35+00:00

Keywords: toxicologic pathology; safety assessment; quality assurance. This issue of Toxicologic Pathology contains an article by Morton et al. that provides recommendations for pathology peer review of nonclinical studies. This is overall a clear, very detailed, and very well-organized manuscript summarizing current recommended practices by experts in the profession and clearly defines the [...]

Pathology Peer Review 2017-01-11T22:13:35+00:00

Triclosan: A Critical Review Of The Experimental Data And Development Of Margins Of Safety For Consumer Products

2017-01-11T22:13:35+00:00

Triclosan (2,4,4′-trichloro-2′-hydroxy-diphenyl ether) is an antibacterial compound that has been used in consumer products for about 40 years. The tolerability and safety of triclosan has been evaluated in human volunteers with little indication of toxicity or sensitization. Although information in humans from chronic usage of personal care products is not available, triclosan has [...]

Triclosan: A Critical Review Of The Experimental Data And Development Of Margins Of Safety For Consumer Products 2017-01-11T22:13:35+00:00

Left-Sided Cardiac Valvulitis in Tristetraprolin-Deficient Mice

2017-01-11T22:13:35+00:00

The Role of Tumor Necrosis Factor α Inflammation may play a role in the etiology of both degenerative and rheumatic cardiac valve diseases. We report here that mice deficient in tristetraprolin (TTP), a protein with known anti-inflammatory functions, develop severe left-sided cardiac valvulitis. TTP is an mRNA binding protein that inhibits inflammation by [...]

Left-Sided Cardiac Valvulitis in Tristetraprolin-Deficient Mice 2017-01-11T22:13:35+00:00

Urban Air Pollution: Influences On Olfactory Function And Pathology In Exposed Children And Young Adults

2017-01-11T22:13:35+00:00

Mexico City (MC) residents are exposed to severe air pollution and exhibit olfactory bulb inflammation. We compared the olfactory function of individuals living under conditions of extreme air pollution to that of controls from a relatively clean environment and explore associations between olfaction scores, apolipoprotein E (APOE) status, and pollution exposure. The olfactory [...]

Urban Air Pollution: Influences On Olfactory Function And Pathology In Exposed Children And Young Adults 2017-01-11T22:13:35+00:00

Molecular Mri for Sensitive and Specific Detection of Lung Metastases

2017-01-11T22:13:35+00:00

Early and specific detection of metastatic cancer cells in the lung (the most common organ targeted by metastases) could significantly improve cancer treatment outcomes. However, the most widespread lung imaging methods use ionizing radiation and have low sensitivity and/or low specificity for cancer cells. Here we address this problem with an imaging method [...]

Molecular Mri for Sensitive and Specific Detection of Lung Metastases 2017-01-11T22:13:35+00:00