Toxicologic Pathology Articles

/Toxicologic Pathology Articles

Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential

2018-05-05T19:48:00+00:00

Quercetin and its glycosides possess potential benefits to human health. Several flavonols are available to consumers as dietary supplements, promoted as anti-oxidants; however, incorporation of natural quercetin glycosides into food and beverage products has been limited by poor miscibility in water. Enzymatic conjugation of multiple glucose moieties to isoquercitrin to produce alpha-glycosyl isoquercitrin (AGIQ) enhances solubility and bioavailability. AGIQ is used in Japan [...]

Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential 2018-05-05T19:48:00+00:00

Role of Pathology Peer Review in Interpretation of the Comet Assay

2018-05-05T16:53:55+00:00

When a comet assay, an increasingly popular in vivo genotoxicity test, shows a positive test result, interpretation of that response requires ruling out any confounding tissue site toxicity. Since the comet assay typically uses only 2 or 3 daily doses of test agent, precursor tissue changes indicative of toxicity may be easily overlooked. [...]

Role of Pathology Peer Review in Interpretation of the Comet Assay 2018-05-05T16:53:55+00:00

New Technologies: Real-time Telepathology Systems – Novel Cost-effective Tools for Real-time Consultation and Data Sharing

2017-12-15T03:08:36+00:00

Abstract: Real-time telepathology for use in investigative and regulated preclinical toxicology studies is now feasible. Newly developed microscope-integrated telepathology systems enable geographically remote stakeholders to view the live histopathology slide as seen by the study pathologist within the microscope. Simultaneous online viewing and dialog between study pathologist and remote colleagues is an efficient [...]

New Technologies: Real-time Telepathology Systems – Novel Cost-effective Tools for Real-time Consultation and Data Sharing 2017-12-15T03:08:36+00:00

Imaging Applications in Toxicologic Pathology – Recommendations for Use in Regulated Non-Clinical Toxicity Studies

2017-06-26T20:01:37+00:00

Available imaging systems for use in preclinical toxicology studies increasingly show utility as important tools in the toxicologic pathologist’s armamentarium, permit longitudinal evaluation of functional and morphological changes in tissues, and provide important information such as organ and lesion volume not obtained by conventional toxicology study parameters. Representative examples of practical applications in [...]

Imaging Applications in Toxicologic Pathology – Recommendations for Use in Regulated Non-Clinical Toxicity Studies 2017-06-26T20:01:37+00:00

Compact Magnetic Resonance Imaging Systems – Novel Cost-Effective Tools for Preclinical Drug Safety and Efficacy Evaluation

2017-05-18T21:43:38+00:00

Practical magnetic resonance imaging for use in investigative and preclinical toxicology studies is now feasible. Newly developed, self-containing imaging systems provide an efficient and cost-effective means to rapidly obtain in vivo and ex vivo magnetic resonance imaging images to improve how we perform toxicology and toxicologic pathology. Drug development is a lengthy and highly [...]

Compact Magnetic Resonance Imaging Systems – Novel Cost-Effective Tools for Preclinical Drug Safety and Efficacy Evaluation 2017-05-18T21:43:38+00:00

Recommendations from the INHAND Apoptosis/Necrosis Working Group

2017-01-11T22:14:41+00:00

Historically, there has been confusion relating to the diagnostic nomenclature for individual cell death. Toxicologic pathologists have generally used the terms “single cell necrosis” and “apoptosis” interchangeably. Increased research on the mechanisms of cell death in recent years has led to the understanding that apoptosis and necrosis involve different cellular pathways and that [...]

Recommendations from the INHAND Apoptosis/Necrosis Working Group 2017-01-11T22:14:41+00:00

Ninety-day toxicity and single-dose toxicokinetics study of alpha-glycosyl isoquercitrin in Sprague-Dawley rat

2017-01-11T22:14:41+00:00

alpha-Glycosyl isoquercitrin (AGIQ) is highly absorbable and has been shown to possess antioxidative properties. Based on a favorable safety profile, it has been confirmed as generally recognized as safe (GRAS) compound by the FDA. Nevertheless, safety and toxicity information for AGIQ is still sparse. Therefore, the aim of this study was to test [...]

Ninety-day toxicity and single-dose toxicokinetics study of alpha-glycosyl isoquercitrin in Sprague-Dawley rat 2017-01-11T22:14:41+00:00

Genotoxicity Assessment of the Flavouring Agent, Perillaldehyde

2017-01-11T22:14:41+00:00

Perillaldehyde, a natural monocyclic terpenoid found most abundantly in the herb perilla, has a long history of use as a flavouring ingredient to add spiciness and citrus taste to foods. Previously, it was judged to be safe by several international expert panels. To confirm the safety of flavourings placed on the European Union [...]

Genotoxicity Assessment of the Flavouring Agent, Perillaldehyde 2017-01-11T22:14:41+00:00

The Legacy of the F344 Rat as a Cancer Bioassay Model (A Retrospective Summary of Three Common F344 Neoplasms)

2017-01-11T22:13:21+00:00

Robert R. Maronpot1, Abraham Nyska2, Jennifer E. Foreman3, Yuval Ramot4 1Maronpot Consulting LLC, Raleigh, North Carolina, USA, 2Sackler School of Medicine, Tel Aviv University and Timrat, Israel, 3ExxonMobil Biomedical Sciences, Inc., Annadale, New Jersey, USA,  4Hadassah-Hebrew University Medical Center, Jerusalem, Israel Keywords: Mononuclear cell leukemia, LGL leukemia, Leydig cell tumor, tunica vaginalis mesothelioma, cancer [...]

The Legacy of the F344 Rat as a Cancer Bioassay Model (A Retrospective Summary of Three Common F344 Neoplasms) 2017-01-11T22:13:21+00:00

Genetic and Rat Toxicity Studies of Cyclodextrin Glucanotransferase

2017-01-11T22:13:22+00:00

Highlights • Bacterial cyclodextrin glucanotransferase (CGTase) is used to produce a water soluble form of glycosylated isoquercitrin. • Genotoxicity battery on CGTase and sodium sulfate negative for mutations and DNA damage. • No evidence of systemic toxicity in 90-day rat toxicity study of CGTase Introduction Microbiologically derived cyclodextrin glucanotransferase (CGTase) is used commercially as a processing [...]

Genetic and Rat Toxicity Studies of Cyclodextrin Glucanotransferase 2017-01-11T22:13:22+00:00