Continuous exposure to α-glycosyl isoquercitrin from developmental stages to adulthood is necessary for facilitating fear extinction learning in ratsContinuous exposure to α-glycosyl isoquercitrin from developmental stages to adulthood is necessary for facilitating fear extinction learning in rats
Continuous exposure to α-glycosyl isoquercitrin from developmental stages to adulthood is necessary for facilitating fear extinction learning in rats
We previously reported that exposure to α-glycosyl isoquercitrin (AGIQ) from the fetal stage to adulthood facilitated fear extinction learning in rats. The present study investigated the specific AGIQ exposure period sufficient for inducing [...]
Synthetic and Natural Food Colorants
There is increasing contemporary appeal and interest in natural versus synthetic food and beverage colorants based on increasing health awareness and global demand for chemical-free food products. There are many commonalities in defining [...]
Safety Assessment Testing Requirements for Food Color Additives
Safety assessment of food colorants are fundamentally similar in Japan, Europe, and the United States and involve large amounts of data for new colorants and active monitoring of existing approved colorants. Testing requirement [...]
The Pathology of Selected Dietary Herbal Medicines as Observed in the National Toxicology Program Studies
The popularity of herbal medicines is growing steadily all over the world, and a large number of people are using these products for self-medication. Although these medicines are being widely used, and the [...]
Food Color Additives
This issue of the Foods and Food Ingredients of Japan includes a special section of papers that focus on synthetic and natural food additive colorants with presentation of governmental regulatory procedures in the [...]
Identification of compound causing yellow bone discoloration following alpha-glycosyl isoquercitrin exposure in Sprague–Dawley rats
Previous rat toxicity studies of alpha-glycosyl isoquercitrin (AGIQ), a water-soluble flavonol glycoside derived from rutin, revealed systemic yellow bone discoloration. This investigative study was conducted to determine the AGIQ metabolite(s) responsible for the [...]
Contemporary activities of Toxicologic Pathology Societies
Educational activities and training opportunities in toxicologic pathology are major goals of 9 formally established Toxicologic Pathology Societies and the International Academy of Toxicologic Pathology. Some Toxicologic Pathology Societies have examination-based certification programs [...]
Contemporary Activities of Toxicologic Pathology Societies (SAGE)
Abstract: Educational activities and training opportunities in toxicologic pathology are major goals of 9 formally established Toxicologic Pathology Societies and the International Academy of Toxicologic Pathology. Some Toxicologic Pathology Societies have examination-based certification [...]
Lack of preventive effect of maternal exposure to α-glycosyl isoquercitrin and α-lipoic acid on developmental hypothyroidism-induced aberrations of hippocampal neurogenesis in rat offspringLack of preventive effect of maternal exposure to α-glycosyl isoquercitrin and α-lipoic acid on developmental hypothyroidism-induced aberrations of hippocampal neurogenesis in rat offspring
Lack of preventive effect of maternal exposure to α-glycosyl isoquercitrin and α-lipoic acid on developmental hypothyroidism-induced aberrations of hippocampal neurogenesis in rat offspring
Hypothyroidism during the developmental stage induces disruption of hippocampal neurogenesis in later life, as well as inducing oxidative stress in the brain. The present study investigated the preventive effect of co-exposure to an [...]
Pathology of the Liver and Gallbladder
Abstract: The liver is a major metabolic organ, and the first site of contact of xenobiotics follows oral ingestion or administration. The primary functional unit of the liver is the hepatic lobule. Gradients [...]
Ten-day and four-week toxicity and toxicokinetics studies of alpha-glycosyl isoquercitrin in juvenile Göttingen minipigs
Background: Alpha-glycosyl isoquercitrin (AGIQ) is widely used as an anti-oxidative food additive in many products. Nevertheless, information on its safety and toxicity is still very limited. A 90-day toxicity study in rats and [...]
Ameliorating effect of postweaning exposure to antioxidant on disruption of hippocampal neurogenesis induced by developmental hypothyroidism in rats
Developmental hypothyroidism as a model of autism spectrum disorders disrupts hippocampal neurogenesis through the adult stage. The present study investigated the ameliorating effect of postweaning exposure to antioxidant on the hypothyroidism-induced disruptive neurogenesis. [...]