Robert Maronpot

About Robert Maronpot

Dr. Maronpot received his doctorate of veterinary medicine in 1965 from Michigan State University, an MS in nutritional pathology from Michigan State University in 1966, and an MPH from Harvard University in 1972. He is a diplomate of the American College of Veterinary Pathologists as well as the American Board of Toxicology and has worked more than forty years in experimental pathology, with an emphasis on animal models of carcinogenesis.

Continuous exposure to α-glycosyl isoquercitrin from developmental stage facilitates fear extinction learning in rats

2019-03-08T20:46:05+00:00

This study investigated the effect of exogenously administered polyphenolic antioxidant, α-glycosyl isoquercitrin (AGIQ), on neural function in rats following dietary exposure at 0.5% from gestational day 6 to postnatal day 77, in comparison with nonpolyphenolic α-lipoic acid (ALA) at 0.2%. AGIQ-exposed offspring revealed enhanced fear extinction learning at the 3rd trial and transcript [...]

Continuous exposure to α-glycosyl isoquercitrin from developmental stage facilitates fear extinction learning in rats2019-03-08T20:46:05+00:00

Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin

2019-03-08T20:45:15+00:00

A 24-month oral carcinogenicity study of permethrin was conducted by feeding male and female CD-1 mice diets containing concentrations of 0, 20, 500, and 2,000 ppm of permethrin (males) or 0, 20, 2,500, and 5,000 ppm of permethrin (females). After approximately two years on study, surviving mice were sacrificed for the evaluation of [...]

Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin2019-03-08T20:45:15+00:00

In Vivo Imaging With Confirmation by Histopathology for Increased Rigor and Reproducibility in Translational Research: A Review of Examples, Options, and Resources

2019-03-08T15:48:10+00:00

Preclinical noninvasive imaging can be an indispensable tool for studying animal models of disease. In vivo imaging to assess anatomical, functional, and molecular features requires verification by a comparison to the macroscopic and microscopic morphological features, since all noninvasive in vivo imaging methods have much lower resolution than standard histopathology. Comprehensive pathological evaluation [...]

In Vivo Imaging With Confirmation by Histopathology for Increased Rigor and Reproducibility in Translational Research: A Review of Examples, Options, and Resources2019-03-08T15:48:10+00:00

Utilizing novel telepathology system in preclinical studies and peer review

2019-01-13T17:57:33+00:00

The demand for board certified toxicologic pathologists and expansion of IT capabilities has resulted in an increase of “virtual” and “distance” pathology (telepathology), and a need for greater flexibility in real time consultations. Newly developed microscope-integrated telepathology systems enable geographically remote stakeholders to view the live histopathology slide as seen by the microscope [...]

Utilizing novel telepathology system in preclinical studies and peer review2019-01-13T17:57:33+00:00

Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats

2019-01-13T18:01:28+00:00

Mineralocorticoid receptor (MR)/NADPH oxidase (NOX) signaling is involved in the development of obesity, insulin resistance, and renal diseases; however, the role of this signaling on steatotic preneoplastic liver lesions is not fully elucidated. We determined the effects of the MR antagonist potassium canrenoate (PC) on MR/NOX signaling in hepatic steatosis and preneoplastic glutathione S-transferase [...]

Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats2019-01-13T18:01:28+00:00

Spironolactone in Combination with Alpha-glycosyl Isoquercitrin Prevents Steatosis-related Early Hepatocarcinogenesis in Rats through the Observed NADPH Oxidase Modulation

2018-11-09T18:06:07+00:00

Administration of the diuretic, spironolactone (SR), can inhibit chronic liver diseases. We determined the effects of SR alone or in combination with the antioxidant α-glycosyl isoquercitrin (AGIQ) on hyperlipidemia- and steatosis-related precancerous lesions in high-fat diet (HFD)-fed rats subjected to a two-stage hepatocarcinogenesis model. Rats were fed with control basal diet or HFD, [...]

Spironolactone in Combination with Alpha-glycosyl Isoquercitrin Prevents Steatosis-related Early Hepatocarcinogenesis in Rats through the Observed NADPH Oxidase Modulation2018-11-09T18:06:07+00:00

Genotoxicity evaluation of the naturally-derived food colorant, gardenia blue, and its precursor, genipin

2018-11-08T21:04:21+00:00

Gardenia blue is widely used in Eastern Asia as a natural food colorant. To evaluate the genotoxic potential of gardenia blue, as well as genipin, the natural starting material from which it is produced, a GLP-compliant test battery was conducted according to OECD guidelines. No evidence of mutagenicity of gardenia blue was detected in a 5-strain bacterial reverse [...]

Genotoxicity evaluation of the naturally-derived food colorant, gardenia blue, and its precursor, genipin2018-11-08T21:04:21+00:00

Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential

2018-05-05T19:48:00+00:00

Quercetin and its glycosides possess potential benefits to human health. Several flavonols are available to consumers as dietary supplements, promoted as anti-oxidants; however, incorporation of natural quercetin glycosides into food and beverage products has been limited by poor miscibility in water. Enzymatic conjugation of multiple glucose moieties to isoquercitrin to produce alpha-glycosyl isoquercitrin (AGIQ) enhances solubility and bioavailability. AGIQ is used in Japan [...]

Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential2018-05-05T19:48:00+00:00

Role of Pathology Peer Review in Interpretation of the Comet Assay

2018-11-09T17:25:51+00:00

When a comet assay, an increasingly popular in vivo genotoxicity test, shows a positive test result, interpretation of that response requires ruling out any confounding tissue site toxicity. Since the comet assay typically uses only 2 or 3 daily doses of test agent, precursor tissue changes indicative of toxicity may be easily overlooked. [...]

Role of Pathology Peer Review in Interpretation of the Comet Assay2018-11-09T17:25:51+00:00

New Technologies: Real-time Telepathology Systems – Novel Cost-effective Tools for Real-time Consultation and Data Sharing

2017-12-15T03:08:36+00:00

Abstract: Real-time telepathology for use in investigative and regulated preclinical toxicology studies is now feasible. Newly developed microscope-integrated telepathology systems enable geographically remote stakeholders to view the live histopathology slide as seen by the study pathologist within the microscope. Simultaneous online viewing and dialog between study pathologist and remote colleagues is an efficient [...]

New Technologies: Real-time Telepathology Systems – Novel Cost-effective Tools for Real-time Consultation and Data Sharing2017-12-15T03:08:36+00:00