Robert Maronpot

/Robert Maronpot

About Robert Maronpot

Dr. Maronpot received his doctorate of veterinary medicine in 1965 from Michigan State University, an MS in nutritional pathology from Michigan State University in 1966, and an MPH from Harvard University in 1972. He is a diplomate of the American College of Veterinary Pathologists as well as the American Board of Toxicology and has worked more than forty years in experimental pathology, with an emphasis on animal models of carcinogenesis.

In Vivo Noninvasive Detection of Brown Adipose Tissue through Intermolecular Zero-Quantum MRI

2017-01-11T22:13:22+00:00

Rosa T. Branca , Le Zhang, Warren S. Warren, Edward Auerbach, Arjun Khanna, Simone Degan, Kamil Ugurbil, Robert Maronpot The recent discovery of active Brown Adipose Tissue (BAT) in adult humans has opened new avenues for obesity research and treatment, as reduced BAT activity seem to be implicated in human energy imbalance, diabetes, [...]

In Vivo Noninvasive Detection of Brown Adipose Tissue through Intermolecular Zero-Quantum MRI 2017-01-11T22:13:22+00:00

Carcinogenesis: Mechanisms and Manifestations

2017-01-11T22:13:22+00:00

We foresee cancer research as an increasingly logical science, in which complexities are manifestations of a small set of underlying organizing principles. (Hanahan and Weinberg, 2011) 1. INTRODUCTION 1.1. Overview Cancer is a major cause of debilitation and death in humans and animals. Cancer develops as a function of age, environment, diet, and genetic [...]

Carcinogenesis: Mechanisms and Manifestations 2017-01-11T22:13:22+00:00

Proceedings of the 2013 Joint JSTP/NTP Satellite Symposium

2017-01-11T22:13:22+00:00

The first joint Japanese Society of Toxicologic Pathology (JSTP) and National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri,” was held on January 29th at Okura Frontier Hotel in Tsukuba, Ibaraki, Japan, in advance of the JSTP’s 29th Annual Meeting. The goal of this Symposium was to present current diagnostic pathology or nomenclature [...]

Proceedings of the 2013 Joint JSTP/NTP Satellite Symposium 2017-01-11T22:13:22+00:00

Immunohistochemistry on decalcified rat nasal cavity: trials and successes

2017-01-11T22:13:22+00:00

Immunohistochemical (IHC) staining for Casein Kinase 2 alpha (CK2a), cyclin-dependent kinase inhibitor 1B (p27Kip1), and heat shock protein 90 (HSP90) was performed on four levels of decalcified rat nasal cavity from four male and three female controls following nose-only exposure to ambient air for 5 days. Successful staining with negligible background artifact was [...]

Immunohistochemistry on decalcified rat nasal cavity: trials and successes 2017-01-11T22:13:22+00:00

Evaluation Of 90-day Oral Rat Toxicity Studies On The Food Additive, Gum Ghatti

2017-01-11T22:13:22+00:00

Gum ghatti, a polysaccharide of natural origin, is used in foods as a thickening, gelling, emulsifying and stabilizing agent. In a 90-day toxicity study following Organization for Economic Co-operation and Development (OECD) Guideline #408, male and female Sprague–Dawley rats were exposed to 0 (control), 0.5, 1.5 and 5% gum ghatti in AIN-93M basal [...]

Evaluation Of 90-day Oral Rat Toxicity Studies On The Food Additive, Gum Ghatti 2017-01-11T22:13:22+00:00

Comparative Histomorphological Review of Rat and Human Hepatocellular Proliferative Lesions

2017-01-11T22:13:34+00:00

In this comparative review, histomorphological features of common nonneoplastic and neoplastic hepatocyte lesions of rats and humans are examined using H&E-stained slides. The morphological similarities and differences of both neoplastic (hepatocellular carcinoma and hepatocellular adenoma) and presumptive preneoplastic lesions (large and small cell change in humans and foci of cellular alteration in rats) [...]

Comparative Histomorphological Review of Rat and Human Hepatocellular Proliferative Lesions 2017-01-11T22:13:34+00:00

Regulatory Forum Opinion Piece: The Role of the Toxicologic Pathologist in the Postgenomic Era: Challenges and Opportunities*

2017-01-11T22:13:34+00:00

The “omics,” high-throughput screening, computational modeling, and database mining revolutions have each arrived with euphoric expectations, considerable hand waving, and promises to set toxicity testing priorities and reduce reliance on conventional animal toxicity and carcinogenicity testing. Reflecting back on prior experience with other predictive approaches and alternatives, what follows the rush to endorse [...]

Regulatory Forum Opinion Piece: The Role of the Toxicologic Pathologist in the Postgenomic Era: Challenges and Opportunities* 2017-01-11T22:13:34+00:00

Tracheal Morphologic and Protein Alterations Following Short-Term Cigarette Mainstream Smoke Exposure to Rats

2017-01-11T22:13:34+00:00

A short-term 5-day nose-only cigarette smoke exposure study was conducted in Fisher 344 rats to identify smoke-induced tracheal protein changes. Groups of 10 male and female 5 week old rats were assigned to 1 of 4 exposure groups. Animals received filtered air, or 75, 200 or 400 mg total particulate matter (TPM)/m3 of [...]

Tracheal Morphologic and Protein Alterations Following Short-Term Cigarette Mainstream Smoke Exposure to Rats 2017-01-11T22:13:34+00:00

Liver Hypertrophy: A Review of Adaptive (Adverse and Non-adverse) Changes—Conclusions from the 3rd International ESTP Expert Workshop

2017-01-11T22:13:34+00:00

Preclinical toxicity studies have demonstrated that exposure of laboratory animals to liver enzyme inducers during preclinical safety assessment results in a signature of toxicological changes characterized by an increase in liver weight, hepatocellular hypertrophy, cell proliferation, and, frequently in long-term (life-time) studies, hepatocarcinogenesis. Recent advances over the last decade have revealed that for [...]

Liver Hypertrophy: A Review of Adaptive (Adverse and Non-adverse) Changes—Conclusions from the 3rd International ESTP Expert Workshop 2017-01-11T22:13:34+00:00

Evaluation Of The Genotoxicity Of The Food Additive, Gum Ghatti

2017-01-11T22:13:35+00:00

Gum ghatti is a food additive in some parts of the world, serving as an emulsifier, a stabilizer, and a thickening agent. To evaluate its genotoxic potential, we conducted Good Laboratory Practice compliant in vitro and in vivo studies in accordance with the Organisation for Economic Co-operation and Development (OECD) guidelines. No evidence [...]

Evaluation Of The Genotoxicity Of The Food Additive, Gum Ghatti 2017-01-11T22:13:35+00:00