Recommendations from the INHAND Apoptosis/Necrosis Working Group
Historically, there has been confusion relating to the diagnostic nomenclature for individual cell death. Toxicologic pathologists have generally used the terms “single cell necrosis” and “apoptosis” interchangeably. Increased research on the mechanisms of [...]
Ninety-day toxicity and single-dose toxicokinetics study of alpha-glycosyl isoquercitrin in Sprague-Dawley rat
alpha-Glycosyl isoquercitrin (AGIQ) is highly absorbable and has been shown to possess antioxidative properties. Based on a favorable safety profile, it has been confirmed as generally recognized as safe (GRAS) compound by the [...]
Genotoxicity Assessment of the Flavouring Agent, Perillaldehyde
Perillaldehyde, a natural monocyclic terpenoid found most abundantly in the herb perilla, has a long history of use as a flavouring ingredient to add spiciness and citrus taste to foods. Previously, it was [...]
The Legacy of the F344 Rat as a Cancer Bioassay Model (A Retrospective Summary of Three Common F344 Neoplasms)
Robert R. Maronpot1, Abraham Nyska2, Jennifer E. Foreman3, Yuval Ramot4 1Maronpot Consulting LLC, Raleigh, North Carolina, USA, 2Sackler School of Medicine, Tel Aviv University and Timrat, Israel, 3ExxonMobil Biomedical Sciences, Inc., Annadale, New Jersey, [...]
Genetic and Rat Toxicity Studies of Cyclodextrin Glucanotransferase
Highlights • Bacterial cyclodextrin glucanotransferase (CGTase) is used to produce a water soluble form of glycosylated isoquercitrin. • Genotoxicity battery on CGTase and sodium sulfate negative for mutations and DNA damage. • No evidence of systemic [...]
Recommendations from the INHAND Apoptosis/Necrosis Working Group
Historically, there has been confusion relating to the diagnostic nomenclature for individual cell death. Toxicologic pathologists have generally used the terms ‘‘single cell necrosis’’ and ‘‘apoptosis’’ interchangeably. Increased research on the mechanisms of [...]
Safety Assessment and Single-dose Toxicokinetics of the Flavouring Agent Myricitrin in Sprague–Dawley Rats
Myricitrin, a flavonol rhamnoside of myricetin extracted from the Chinese bayberry (Myrica rubra Siebold) plant, has been used in Japan since 1992 as a flavour modifier in snack foods, dairy products, and beverages. [...]
Genotoxicity Evaluation of the Flavonoid, Myricitrin, and its Aglycone, Myricetin
Myricitrin, a flavonoid extracted from the fruit, leaves, and bark of Chinese bayberry (Myrica rubra SIEBOLD), is currently used as a flavor modifier in snack foods, dairy products, and beverages in Japan. Myricitrin is [...]
Toxicological Assessment of Ashitaba Chalcone
The plant Angelica keiskei contains two main physiologically active flavonoid chalcones, 4-hydroxyderricin and xanthoangelol. Known as ashitaba in Japan, powder from the sap is widely consumed for its medicinal properties in Asia as [...]
Human Relevance Of Rodent Leydig Cell Tumors
Rodents have been used extensively in virtually all fields of biomedical research and have been the primary species used in toxicologic and carcinogenic research. Over many years it has become obvious that some [...]
Two-year Carcinogenicity Study of Acrylamide in Wistar Han Rats with In Utero Exposure
Acrylamide is an important chemical with widespread industrial and other uses in addition to generalized population exposure from certain cooked foods. Previous rat studies to assess the carcinogenic potential of acrylamide have been [...]
Practical Applications of in Vivo and ex Vivo MRI in Toxicologic Pathology Using a Novel High-performance Compact MRI System
Catherine Tempel-Brami, Yael S. Schiffenbauer, Abraham Nyska, Nati Ezov, Itai Spector, Rinat abramovitch, and Robert R. Maronpot Magnetic resonance imaging (MRI) is widely used in preclinical research and drug development and is a [...]