Evaluation Of The Genotoxicity Of The Food Additive, Gum Ghatti
Gum ghatti is a food additive in some parts of the world, serving as an emulsifier, a stabilizer, and a thickening agent. To evaluate its genotoxic potential, we conducted Good Laboratory Practice compliant [...]
Responsible Authorship and Publication Practices
Robert R. Maronpot A panel and audience discussion co-sponsored by the International Academy of Toxicologic Pathology (IATP) and the Society of Toxicologic Pathology (STP) at the STP Annual Meeting in Denver in June [...]
Proceedings of the 2010 National Toxicology Program Satellite Symposium
The 2010 annual National Toxicology Program (NTP) Satellite Symposium, entitled ‘‘Pathology Potpourri,’’ was held in Chicago, Illinois, in advance of the scientific symposium sponsored jointly by the Society of Toxicologic Pathology (STP) and [...]
Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System
The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan [...]
Liver Enlargement – Hepatic Enzyme Induction: Histopathology
Hepatic enzyme induction is generally an adaptive response associated with increases in liver weight, induction of gene expression, and morphological changes in hepatocytes. The additive growth and functional demands that initiated the response [...]
Introduction to Hepatic Drug Metabolizing Enzyme Induction in Drug Safety Evaluation Studies
The following three articles represent the output of a combined effort initiated by the Scientific Regulatory Policy Committee of the Society of Toxicologic Pathology to provide a unified review of current scientific practices [...]
Pathology Peer Review
Keywords: toxicologic pathology; safety assessment; quality assurance. This issue of Toxicologic Pathology contains an article by Morton et al. that provides recommendations for pathology peer review of nonclinical studies. This is overall a [...]
Triclosan: A Critical Review Of The Experimental Data And Development Of Margins Of Safety For Consumer Products
Triclosan (2,4,4′-trichloro-2′-hydroxy-diphenyl ether) is an antibacterial compound that has been used in consumer products for about 40 years. The tolerability and safety of triclosan has been evaluated in human volunteers with little indication [...]
Left-Sided Cardiac Valvulitis in Tristetraprolin-Deficient Mice
The Role of Tumor Necrosis Factor α Inflammation may play a role in the etiology of both degenerative and rheumatic cardiac valve diseases. We report here that mice deficient in tristetraprolin (TTP), a [...]
Urban Air Pollution: Influences On Olfactory Function And Pathology In Exposed Children And Young Adults
Mexico City (MC) residents are exposed to severe air pollution and exhibit olfactory bulb inflammation. We compared the olfactory function of individuals living under conditions of extreme air pollution to that of controls [...]
Molecular Mri for Sensitive and Specific Detection of Lung Metastases
Early and specific detection of metastatic cancer cells in the lung (the most common organ targeted by metastases) could significantly improve cancer treatment outcomes. However, the most widespread lung imaging methods use ionizing [...]
Proceedings of the 2009 National Toxicology Program Satellite Symposium
The National Toxicology Program (NTP) Satellite Symposium is a one-day meeting that is held in conjunction with the annual Society of Toxicologic Pathology (STP) meeting. The topic of the 2009 Symposium was ‘‘Tumor [...]